Adolfsson R, Gottfries C G, Roos B E, Winblad B
J Neural Transm. 1979;45(2):81-105. doi: 10.1007/BF01250085.
The post-mortem brain concentrations of dopamine (DA) and homovanillic acid (HVA) were determined in 16 parts of the brain from patients with no history of neurologic or psychiatric illness. Fifteen men and nine women, with a mean age of 61.0 +/- 18.7 years (range 23--92 years) were included. They had died from either ischaemic heart disease or cancer. In the post-mortem investigation several factors were controlled: age, time between death and autopsy, time between autopsy and chemical analysis and storage time (-20 degrees C). The DA concentrations in the different brain areas were found to be positively intercorrelated, especially those in the basal ganglia, hippocampus and the mesencephalon. The HVA concentrations measured in various cortical structures were also positively intercorrelated. In several regions of the brain there was a significant inverse correlation between the DA and HVA concentrations. The DA and HVA concentrations did not differ according to sex, but age had a marked influence on the DA concentration. Significant decrease with age was observed in the nucleus caudatus, globus pallidus, mesencephalon, hippocampus and in the cortex gyrus hippocampus. These findings are discussed in relation to the effect of aging neurons. A review of human post-mortem investigations on DA and HVA concentrations is also presented.
测定了无神经或精神疾病病史患者大脑16个区域的尸检脑内多巴胺（DA）和高香草酸（HVA）浓度。纳入了15名男性和9名女性，平均年龄为61.0±18.7岁（范围23 - 92岁）。他们死于缺血性心脏病或癌症。在尸检调查中控制了几个因素：年龄、死亡与尸检之间的时间、尸检与化学分析之间的时间以及储存时间（-20℃）。发现不同脑区的DA浓度呈正相关，尤其是基底神经节、海马体和中脑的DA浓度。在各种皮质结构中测量的HVA浓度也呈正相关。在大脑的几个区域，DA和HVA浓度之间存在显著的负相关。DA和HVA浓度在性别上没有差异，但年龄对DA浓度有显著影响。在尾状核、苍白球、中脑、海马体和海马回皮质中观察到随着年龄增长DA浓度显著下降。结合衰老神经元的影响对这些发现进行了讨论。还对人类关于DA和HVA浓度的尸检研究进行了综述。
