Ljungberg B, Blombäck M, Johnsson H, Lins L E
Clin Nephrol. 1987 Jan;27(1):31-5.
A low molecular heparin fragment (Fragmin, mol. wt. 4-6000 d), given as a single injection (dose 5000 anti-Xa U), was used as an anticoagulant during hemodialysis in 11 patients. In comparison, our routine heparinization procedure was used; conventional heparin was given as a bolus injection at the start and then as continuous infusion during dialysis to prolong the whole blood activated clotting time (WBACT) 125-175%. Fibrin formation, followed by visual inspection and the measuring of fibrinopeptide A and fibrin monomer concentrations were equally suppressed by the two regimens. WBACT was less prolonged with Fragmin. Anti-Xa activity above 0.39 U/ml was maintained throughout the dialyses with Fragmin. In conclusion a single dose of Fragmin gives sufficient anticoagulation for hemodialysis lasting up to 4 hours.
一种低分子肝素片段（速碧林，分子量4 - 6000道尔顿），单次注射（剂量5000抗Xa单位），用于11例患者血液透析期间的抗凝。作为对照，采用我们的常规肝素化程序；常规肝素在开始时静脉推注，然后在透析期间持续输注，以使全血活化凝血时间（WBACT）延长125% - 175%。两种方案对纤维蛋白形成的抑制效果相当，通过肉眼观察以及测量纤维蛋白肽A和纤维蛋白单体浓度来评估。使用速碧林时WBACT延长较少。在整个使用速碧林的透析过程中，抗Xa活性维持在0.39单位/毫升以上。总之，单剂量的速碧林可为长达4小时的血液透析提供足够的抗凝作用。
