Ljungberg B
Clin Nephrol. 1985 Jul;24(1):15-20.
During 18 hemodialyses of patients with chronic uremia a low molecular weight heparin fraction (mean MW 5000 d) was used as an anticoagulant without complications. For comparison conventional heparin was used during 18 dialyses in the same patients. Equipotent doses, with regard to Xa inhibition of heparin and the 5000d fraction, suppressed FPA generation (fibrin formation) equally. The APT-times were less prolonged by the 5000d fraction. When the 5000d fraction was doubled in relation to conventional heparin with regard to Xa inhibition, the suppression of FPA generation was more effective than with conventional heparin, without more pronounced APTT prolongations. In conclusion this heparin fraction was found to be useful as an anticoagulant during hemodialysis and to give less pronounced APTT prolongation than conventional heparin.
在对慢性尿毒症患者进行的18次血液透析过程中，使用了一种低分子量肝素片段（平均分子量5000道尔顿）作为抗凝剂，未出现并发症。作为对照，在对相同患者进行的另外18次透析过程中使用了常规肝素。就对Xa的抑制作用而言，肝素和5000道尔顿片段的等效剂量对FPA生成（纤维蛋白形成）的抑制作用相同。5000道尔顿片段使活化部分凝血活酶时间（APTT）延长的程度较小。当5000道尔顿片段在抑制Xa方面相对于常规肝素剂量加倍时，其对FPA生成的抑制作用比常规肝素更有效，且不会使APTT延长更明显。总之，发现这种肝素片段在血液透析期间作为抗凝剂是有用的，并且与常规肝素相比，其使APTT延长的程度较小。
