Xing Yifan, Zhang Qian, Jiu Yaming
Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
Subcell Biochem. 2023;106:333-364. doi: 10.1007/978-3-031-40086-5_12.
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and undertakes many fundamental life activities. Among them, actin filaments are mainly responsible for maintaining cell shape and mediating cell movement, microtubules are in charge of coordinating all cargo transport within the cell, and intermediate filaments are mainly thought to guard against external mechanical pressure. In addition to this, cytoskeleton networks are also found to play an essential role in multiple viral infections. Due to the COVID-19 epidemic, including SARS-CoV-2, SARS-CoV and MERS-CoV, so many variants have caused wide public concern, that any virus infection can potentially bring great harm to human beings and society. Therefore, it is of great importance to study coronavirus infection and develop antiviral drugs and vaccines. In this chapter, we summarize in detail how the cytoskeleton responds and participates in coronavirus infection by analyzing the possibility of the cytoskeleton and its related proteins as antiviral targets, thereby providing ideas for finding more effective treatments.
细胞骨架包括肌动蛋白丝、微管和中间丝，是细胞中最重要的网络之一，承担着许多基本的生命活动。其中，肌动蛋白丝主要负责维持细胞形状和介导细胞运动，微管负责协调细胞内的所有货物运输，而中间丝主要被认为是抵御外部机械压力的。除此之外，还发现细胞骨架网络在多种病毒感染中起着至关重要的作用。由于包括SARS-CoV-2、SARS-CoV和MERS-CoV在内的COVID-19疫情，如此多的变种引起了公众的广泛关注，任何病毒感染都可能给人类和社会带来巨大危害。因此，研究冠状病毒感染并开发抗病毒药物和疫苗至关重要。在本章中，我们通过分析细胞骨架及其相关蛋白作为抗病毒靶点的可能性，详细总结了细胞骨架如何响应并参与冠状病毒感染，从而为寻找更有效的治疗方法提供思路。
