Clinical Neurology Unit, Department of Head-neck and Neurosciences, Udine University Hospital, Piazzale Santa Maria Della Misericordia 15, 33100, Udine, Italy.
Clinical Neurology Unit, Department of Head-neck and Neurosciences, Udine University Hospital, Piazzale Santa Maria Della Misericordia 15, 33100, Udine, Italy.
Toxicon. 2024 Feb 1;238:107565. doi: 10.1016/j.toxicon.2023.107565. Epub 2023 Dec 29.
Numb chin syndrome is a rare pain disorder characterized by decreased sensation and paresthesia in the territory of the mental nerve. Neuropathic pain is sometimes described in this setting, and the most common treatments include oral analgesics, gabapentinoids, and carbamazepine; however, botulinum toxin type A has never been used in this setting. We describe a case of bilateral numb chin syndrome, secondary to Burkitt lymphoma, associated with refractory and persistent burning neuropathic pain, effectively treated twelve times with subcutaneous Botulinum toxin type A (BoNT/A) injections. The procedure was well tolerated, but the patient reported incomplete mouth closure of minimal entity. BoNT/A could be a safe and effective therapy for neuropathic pain associated with numb chin syndrome.
麻木下巴综合征是一种罕见的疼痛障碍，其特征是下颌神经支配区域感觉减退和感觉异常。在这种情况下有时会出现神经病理性疼痛，最常见的治疗方法包括口服镇痛药、加巴喷丁类药物和卡马西平；然而，肉毒杆菌毒素 A 从未在此类情况下使用过。我们描述了一例双侧麻木下巴综合征，继发于伯基特淋巴瘤，伴有难治性和持续性灼痛神经病理性疼痛，经十二次皮下肉毒杆菌毒素 A（BoNT/A）注射有效治疗。该过程耐受良好，但患者报告存在轻微的不完全性闭口。BoNT/A 可能是治疗与麻木下巴综合征相关的神经病理性疼痛的一种安全有效的方法。
