Department of Anaesthesiology & Pain Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, Korea.
Department of Anaesthesiology & Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Toxins (Basel). 2017 Aug 24;9(9):260. doi: 10.3390/toxins9090260.
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness, spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to treat various types of neuropathic pain. The mechanism by which BoNT acts on neuropathic pain involves inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerves. Recent journals have demonstrated that BoNT is effective for neuropathic pain, such as postherpetic neuralgia, trigeminal neuralgia, and peripheral neuralgia. The purpose of this review is to summarize the experimental and clinical evidence of the mechanism by which BoNT acts on various types of neuropathic pain and describe why BoNT can be applied as treatment. The PubMed database was searched from 1988 to May 2017. Recent studies have demonstrated that BoNT injections are effective treatments for post-herpetic neuralgia, diabetic neuropathy, trigeminal neuralgia, and intractable neuropathic pain, such as poststroke pain and spinal cord injury.
肉毒毒素（BoNT）已被用于治疗肌肉僵硬、痉挛和肌张力障碍。BoNT 已使用了大约 40 年，最近还被用于治疗各种类型的神经性疼痛。BoNT 作用于神经性疼痛的机制涉及抑制感觉神经中炎症介质和外周神经递质的释放。最近的期刊表明，BoNT 对神经性疼痛（如带状疱疹后神经痛、三叉神经痛和周围神经痛）有效。本综述的目的是总结 BoNT 作用于各种类型神经性疼痛的作用机制的实验和临床证据，并描述为什么 BoNT 可以作为治疗方法。从 1988 年到 2017 年 5 月，在 PubMed 数据库中进行了检索。最近的研究表明，BoNT 注射是治疗带状疱疹后神经痛、糖尿病性神经病、三叉神经痛和难治性神经性疼痛（如中风后疼痛和脊髓损伤）的有效治疗方法。
