Department of Statistics, Texas A&M University, College Station, TX 77843, USA.
Pac Symp Biocomput. 2024;29:201-213.
Digital health technologies such as wearable devices have transformed health data analytics, providing continuous, high-resolution functional data on various health metrics, thereby opening new avenues for innovative research. In this work, we introduce a new approach for generating causal hypotheses for a pair of a continuous functional variable (e.g., physical activities recorded over time) and a binary scalar variable (e.g., mobility condition indicator). Our method goes beyond traditional association-focused approaches and has the potential to reveal the underlying causal mechanism. We theoretically show that the proposed scalar-function causal model is identifiable with observational data alone. Our identifiability theory justifies the use of a simple yet principled algorithm to discern the causal relationship by comparing the likelihood functions of competing causal hypotheses. The robustness and applicability of our method are demonstrated through simulation studies and a real-world application using wearable device data from the National Health and Nutrition Examination Survey.
数字健康技术,如可穿戴设备,已经改变了健康数据分析,为各种健康指标提供了连续的、高分辨率的功能数据,从而为创新研究开辟了新途径。在这项工作中,我们引入了一种新的方法来生成一对连续功能变量(例如,随时间记录的身体活动)和二进制标量变量(例如,移动条件指示器)的因果假设。我们的方法超越了传统的关注关联的方法,有可能揭示潜在的因果机制。我们从理论上表明,仅使用观测数据,所提出的标量-函数因果模型是可识别的。我们的可识别性理论证明了使用简单而有原则的算法通过比较竞争因果假设的似然函数来辨别因果关系的合理性。通过使用来自国家健康和营养检查调查的可穿戴设备数据的模拟研究和实际应用,证明了我们方法的稳健性和适用性。