Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Biometrics. 2021 Mar;77(1):54-66. doi: 10.1111/biom.13269. Epub 2020 May 6.
This paper introduces two sets of measures as exploratory tools to study physical activity patterns: active-to-sedentary/sedentary-to-active rate function (ASRF/SARF) and active/sedentary rate function (ARF/SRF). These two sets of measures are complementary to each other and can be effectively used together to understand physical activity patterns. The specific features are illustrated by an analysis of wearable device data from National Health and Nutrition Examination Survey (NHANES). A two-level semiparametric regression model for ARF and the associated activity magnitude is developed under a unified framework using the marked point process formulation. The inactive and active states measured by accelerometers are treated as a 0-1 point process, and the activity magnitude measured at each active state is defined as a marked variable. The commonly encountered missing data problem due to device nonwear is referred to as "window censoring," which is handled by a proper estimation approach that adopts techniques from recurrent event data. Large sample properties of the estimator and comparison between two regression models as measurement frequency increases are studied. Simulation and NHANES data analysis results are presented. The statistical inference and analysis results suggest that ASRF/SARF and ARF/SRF provide useful analytical tools to practitioners for future research on wearable device data.
本文介绍了两套探索性工具,用于研究身体活动模式:活跃-久坐/久坐-活跃率函数(ASRF/SARF)和活跃/久坐率函数(ARF/SRF)。这两套措施相互补充,可以有效地一起使用,以了解身体活动模式。通过对国家健康和营养检查调查(NHANES)中可穿戴设备数据的分析来说明它们的具体特点。在统一框架下,使用标记点过程公式开发了用于 ARF 和相关活动幅度的两级半参数回归模型。加速度计测量的不活动和活动状态被视为 0-1 点过程,在每个活动状态下测量的活动幅度被定义为标记变量。由于设备未佩戴而导致的常见缺失数据问题被称为“窗口 censoring”,通过采用复发事件数据技术的适当估计方法来处理。研究了估计量的大样本性质和两种回归模型之间的比较,随着测量频率的增加。给出了模拟和 NHANES 数据分析结果。统计推断和分析结果表明,ASRF/SARF 和 ARF/SRF 为实践者提供了有用的分析工具,用于未来对可穿戴设备数据的研究。