Coventry J, King H, Zimmet P, Raper L R, Sicree R
Diabetes Res. 1986 Oct;3(8):427-32.
We report a cross-sectional study of impaired glucose tolerance conducted on data collected during the Fiji Cardiovascular and Metabolic Disease Survey, which was performed in 1980. Both Melanesian Fijians and migrants from the Indian subcontinent were studied. Impaired glucose tolerance and diabetes were defined according to current WHO criteria. When impaired glucose-tolerant subjects were compared with normals and diabetics with respect to selected physiological, biochemical and environmental factors, those with impaired glucose tolerance showed greater affinities with the diabetics than with the normal subjects. This finding was true of both the Melanesian and Indian populations, but was in contrast to a study of Micronesians in Kiribati (using standardized survey methods and similar analyses) in which subjects with impaired glucose tolerance held an intermediate position between normals and diabetics, with respect to the chosen factors. A possible explanation for the discrepant findings of the 2 studies is that the cut-off point in the distribution of plasma glucose concentration which defines diabetes may vary in populations of different ethnic origin, and the studies support the concept of heterogeneity within the category of impaired glucose tolerance.
我们报告了一项基于1980年斐济心血管与代谢疾病调查所收集数据进行的糖耐量受损横断面研究。研究对象包括美拉尼西亚斐济人和来自印度次大陆的移民。糖耐量受损和糖尿病根据世界卫生组织现行标准定义。当将糖耐量受损受试者与正常人和糖尿病患者在选定的生理、生化及环境因素方面进行比较时，糖耐量受损者与糖尿病患者的相似性高于与正常受试者的相似性。这一发现对于美拉尼西亚人和印度人群体均成立，但与一项针对基里巴斯密克罗尼西亚人的研究（采用标准化调查方法及类似分析）形成对比，在该研究中，就所选定因素而言，糖耐量受损受试者在正常人和糖尿病患者之间处于中间位置。这两项研究结果存在差异的一个可能解释是，定义糖尿病的血浆葡萄糖浓度分布的切点在不同种族人群中可能有所不同，且这些研究支持糖耐量受损类别内存在异质性的概念。
