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前瞻性评估具有季节性模式的复发性重度抑郁症患者的夏季情绪状态:SAD 结构效度的证据。

Prospectively assessed summer mood status in major depression, recurrent with seasonal pattern: Evidence for SAD's construct validity.

机构信息

Department of Psychological Science, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405-0134, USA.

Department of Psychological Science, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405-0134, USA.

出版信息

J Affect Disord. 2024 Mar 15;349:32-38. doi: 10.1016/j.jad.2023.12.070. Epub 2023 Dec 30.

Abstract

OBJECTIVE

Seasonal patterns are often undetectable in population-based depression studies, calling into question the existence of winter seasonal affective disorder (SAD). If SAD has construct validity, individuals with SAD should show spontaneous depression remission in the summer. Data are sparse on prospectively assessed summer mood status in confirmed SAD patients.

METHOD

We conducted prospective summer followup of community adults who, the winter before, were diagnosed with Major Depression, Recurrent with Seasonal Pattern on the Structured Clinical Interview for DSM-IV Axis I Disorders, developed a current SAD episode on the Structured Interview Guide for the Hamilton Rating Scale for Depression-Seasonal Affective Disorder Version (SIGH-SAD), and enrolled in a clinical trial comparing group cognitive-behavioral therapy for SAD and light therapy. In July/August after treatment, 143/153 (93.5 %) participants provided data on the SIGH-SAD, the Beck Depression Inventory-Second Edition, and the Longitudinal Interval Followup Evaluation (LIFE).

RESULTS

Summer mean depression scores were in the normal range, with the substantial majority in remission across different measures. On the LIFE, 113/143 (79.0 %) experienced complete summer remission, 19/143 (13.3 %) experienced partial summer remission, and 11/143 (7.7 %) had major depression in the summer. Depression scores were significantly lower at summer than post-treatment in both treatments, indicating incomplete treatment response.

LIMITATIONS

This was a single-site study with a relatively homogeneous sample.

CONCLUSIONS

Supporting construct validity for SAD, the substantial majority experienced complete summer remission, with a minority in partial remission and a very small minority in episode. Both treatments left residual symptoms at treatment endpoint compared to summer.

摘要

目的

在基于人群的抑郁症研究中,季节性模式通常难以察觉,这使得冬季季节性情感障碍(SAD)的存在受到质疑。如果 SAD 具有构建效度,那么患有 SAD 的个体在夏季应该会出现自发性抑郁缓解。关于确诊 SAD 患者的前瞻性夏季情绪状况的数据很少。

方法

我们对社区成年人进行了前瞻性夏季随访,这些成年人在冬季之前被诊断患有重性抑郁症,且根据 DSM-IV 轴 I 障碍的结构临床访谈,具有季节性模式的复发性抑郁症,在结构访谈指南上出现了当前的 SAD 发作 Hamilton 抑郁评定量表-季节性情感障碍版(SIGH-SAD),并参加了比较 SAD 团体认知行为疗法和光照疗法的临床试验。在治疗后的 7 月/8 月,143/153(93.5%)名参与者提供了 SIGH-SAD、贝克抑郁量表第二版和纵向间隔随访评估(LIFE)的数据。

结果

夏季平均抑郁评分处于正常范围,绝大多数人在不同的测量指标中都处于缓解状态。在 LIFE 上,113/143(79.0%)人经历了完全的夏季缓解,19/143(13.3%)人经历了部分夏季缓解,11/143(7.7%)人在夏季患有重度抑郁症。与治疗后相比,夏季的抑郁评分明显较低,表明治疗反应不完全。

局限性

这是一项单站点研究,样本相对同质。

结论

支持 SAD 的构建效度,绝大多数人经历了完全的夏季缓解,少数人经历了部分缓解,极少数人经历了发作。与夏季相比,两种治疗方法在治疗终点都留下了残留症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/10923172/44bc3f81da7b/nihms-1960234-f0001.jpg

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