Rohan Kelly J, Mahon Jennifer N, Evans Maggie, Ho Sheau-Yan, Meyerhoff Jonah, Postolache Teodor T, Vacek Pamela M
From the Department of Psychological Science, University of Vermont, and the Department of Medical Biostatistics, University of Vermont College of Medicine, Burlington, Vt.; the Department of Psychiatry, University of Maryland School of Medicine, Baltimore; and Veterans Integrated Service Network (VISN) 5, Mental Illness Research Education and Clinical Center (MIRECC), Baltimore, and VISN 19 Rocky Mountain MIRECC, Denver.
Am J Psychiatry. 2015 Sep 1;172(9):862-9. doi: 10.1176/appi.ajp.2015.14101293. Epub 2015 Apr 10.
Whereas considerable evidence supports light therapy for winter seasonal affective disorder (SAD), data on cognitive-behavioral therapy for SAD (CBT-SAD) are promising but preliminary. This study estimated the difference between CBT-SAD and light therapy outcomes in a large, more definitive test.
The participants were 177 adults with a current episode of major depression that was recurrent with a seasonal pattern. The randomized clinical trial compared 6 weeks of CBT-SAD (N=88) and light therapy (N=89). Light therapy consisted of 10,000-lux cool-white florescent light, initiated at 30 minutes each morning and adjusted according to a treatment algorithm based on response and side effects. CBT-SAD comprised 12 sessions of the authors' SAD-tailored protocol in a group format and was administered by Ph.D. psychologists in two 90-minute sessions per week. Outcomes were continuous scores on the Structured Interview Guide for the Hamilton Rating Scale for Depression-SAD Version (SIGH-SAD, administered weekly) and Beck Depression Inventory-Second Edition (BDI-II, administered before treatment, at week 3, and after treatment) and posttreatment remission status based on cut points.
Depression severity measured with the SIGH-SAD and BDI-II improved significantly and comparably with CBT-SAD and light therapy. Having a baseline comorbid diagnosis was associated with higher depression scores across all time points in both treatments. CBT-SAD and light therapy did not differ in remission rates based on the SIGH-SAD (47.6% and 47.2%, respectively) or the BDI-II (56.0% and 63.6%).
CBT-SAD and light therapy are comparably effective for SAD during an acute episode, and both may be considered as treatment options.
尽管有大量证据支持光疗法治疗冬季季节性情感障碍(SAD),但关于SAD的认知行为疗法(CBT-SAD)的数据虽有前景但尚属初步。本研究在一项规模更大、更具权威性的试验中估计了CBT-SAD与光疗法疗效的差异。
参与者为177名患有当前重度抑郁发作且呈季节性复发的成年人。这项随机临床试验比较了6周的CBT-SAD(n = 88)和光疗法(n = 89)。光疗法采用10000勒克斯的冷白色荧光灯,每天早晨开始照射30分钟,并根据基于反应和副作用的治疗算法进行调整。CBT-SAD采用作者针对SAD量身定制的方案,以小组形式进行12次治疗,由心理学博士每周进行两次90分钟的治疗。疗效指标为抑郁症状严重程度连续评分,采用汉密尔顿抑郁量表季节性情感障碍版结构化访谈指南(SIGH-SAD,每周进行评估)和贝克抑郁量表第二版(BDI-II,在治疗前、第3周和治疗后进行评估),以及基于切点的治疗后缓解状态。
使用SIGH-SAD和BDI-II测量的抑郁严重程度在CBT-SAD和光疗法中均有显著且相当的改善。在两种治疗的所有时间点,基线共病诊断均与较高的抑郁评分相关。基于SIGH-SAD(分别为47.6%和47.2%)或BDI-II(分别为56.0%和63.6%)的缓解率,CBT-SAD和光疗法并无差异。
在急性发作期间,CBT-SAD和光疗法对SAD的疗效相当,均可作为治疗选择。