Julis I, Skrivánková B, Trnavský K
Clin Rheumatol. 1986 Dec;5(4):475-81.
A microfluorometric study of relative DNA content in lymphocytes and granulocytes from the synovial fluid of 26 patients with rheumatoid arthritis or seronegative reactive arthritis was carried out. Results obtained from individuals without treatment or treated with nonsteroid anti-inflammatory drugs were compared with measurements of 7 healthy persons. DNA content in granulocytes was more sensitive to effects of disease or therapy than in lymphocytes. Introduction of therapy resulted in decreased percentage of cells in synthetizing or mitotic phase of the cell division cycle (microfluorometric index showing non G0 (G1 population]. A possible local influence of regulatory substances produced in the arthritic joint on DNA metabolism of both cells under study was suggested.
对26例类风湿性关节炎或血清阴性反应性关节炎患者滑液中的淋巴细胞和粒细胞的相对DNA含量进行了微量荧光测定研究。将未接受治疗或接受非甾体抗炎药治疗的个体的结果与7名健康人的测量结果进行了比较。粒细胞中的DNA含量比淋巴细胞对疾病或治疗的影响更敏感。治疗导致细胞分裂周期合成或有丝分裂期的细胞百分比降低（微量荧光测定指数显示非G0（G1群体））。提示关节炎关节中产生的调节物质可能对所研究的两种细胞的DNA代谢有局部影响。
