Kanstrup I L, Winkler K
Clin Physiol. 1987 Feb;7(1):51-4. doi: 10.1111/j.1475-097x.1987.tb00633.x.
The results from simultaneous measurements of indocyanine green (ICG) plasma clearance and hepatic blood flow (HBF) in subjects without hepatic dysfunction during changes in HBF induced pharmacologically or by food stimulation, are reported. A linear relation is established between the relative changes in HBF and that of ICG clearance (r = 0.94), but the changes are not identical, and therefore the changes in HBF cannot be accurately predicted from that of ICG plasma clearance. The reason behind the lack of identity of the changes lies in the complicated kinetics of dye removal by the liver. The hepatic venous catheterization technique is the only method when physiologically correct values for hepatic blood flow or changes therein are wanted.
本文报告了在无肝功能障碍的受试者中，通过药理学方法或食物刺激诱导肝血流量（HBF）变化时，同时测量吲哚菁绿（ICG）血浆清除率和肝血流量（HBF）的结果。HBF的相对变化与ICG清除率的相对变化之间建立了线性关系（r = 0.94），但变化并不相同，因此不能从ICG血浆清除率的变化准确预测HBF的变化。变化缺乏一致性的原因在于肝脏清除染料的复杂动力学。当需要肝血流量的生理正确值或其变化时，肝静脉插管技术是唯一的方法。
