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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Grainger S L, Keeling P W, Brown I M, Marigold J H, Thompson R P

Clin Sci (Lond). 1983 Feb;64(2):207-12. doi: 10.1042/cs0640207.

The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and non-invasively after a single intravenous injection of ICG.

利用两室药代动力学模型的一种新颖分析方法，对健康人和狒狒静脉注射吲哚菁绿（ICG）后的处置情况进行了研究。2. 这种分析方法能够仅根据血浆消失曲线确定染料的肝提取率（ER），所确定的ER与通过肝静脉插管测量的结果无差异。3. 与稳态时测量的清除率相比，两室模型对血浆清除率的测定比传统的一室模型显著更准确。4. 得出结论，在健康状态下，单次静脉注射ICG后可准确且无创地计算肝血流量。

Grainger S L, Keeling P W, Brown I M, Marigold J H, Thompson R P

Clin Sci (Lond). 1983 Feb;64(2):207-12. doi: 10.1042/cs0640207.

The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and non-invasively after a single intravenous injection of ICG.

利用两室药代动力学模型的一种新颖分析方法，对健康人和狒狒静脉注射吲哚菁绿（ICG）后的处置情况进行了研究。2. 这种分析方法能够仅根据血浆消失曲线确定染料的肝提取率（ER），所确定的ER与通过肝静脉插管测量的结果无差异。3. 与稳态时测量的清除率相比，两室模型对血浆清除率的测定比传统的一室模型显著更准确。4. 得出结论，在健康状态下，单次静脉注射ICG后可准确且无创地计算肝血流量。