用于伤口愈合和药物释放系统的可喷涂碳化钛MXene水凝胶
Sprayable TiC MXene hydrogel for wound healing and drug release system.
作者信息
Park Hyeongtaek, Kim Jeong-Uk, Kim Soojin, Hwang Nathaniel S, Kim Hwan D
机构信息
Department of IT Convergence (BK21 FOUR), Korea National University of Transportation, Chungju, 27469, Republic of Korea.
School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, Seoul, 08826, Republic of Korea.
出版信息
Mater Today Bio. 2023 Nov 28;23:100881. doi: 10.1016/j.mtbio.2023.100881. eCollection 2023 Dec.
Wound healing is a critical process that facilitates the body's recovery from injuries and helps prevent infections, thereby maintaining overall tissue and organ functionality. However, delayed wound healing owing to various factors can lead to bacterial infections and secondary complications. In this study, a ciprofloxacin (CIP)-loaded MXene/sodium alginate (SA) hydrogel was fabricated to inhibit bacterial infections and enhance wound healing. The hydrogel was formulated in a sprayable state by blending CIP-loaded MXene (CIP-MX) with SA. This hydrogel was found to exhibit excellent photothermal conversion capability and biocompatibility under near-infrared (NIR) irradiation. In addition, the hydrogel enabled controlled drug release based on NIR irradiation, ultimately enabling improved antibacterial activity. Based on the and experiments, the CIP-loaded MXene/SA hydrogel (CIP-MX@Gel) accelerated wound healing. Overall, the CIP-MX@Gel has excellent potential as an effective wound healing material.
伤口愈合是一个关键过程，它有助于身体从损伤中恢复，并有助于预防感染，从而维持整体组织和器官的功能。然而，由于各种因素导致的伤口愈合延迟会导致细菌感染和继发性并发症。在本研究中，制备了负载环丙沙星（CIP）的MXene/海藻酸钠（SA）水凝胶，以抑制细菌感染并促进伤口愈合。通过将负载CIP的MXene（CIP-MX）与SA混合，将水凝胶制成可喷雾状态。发现该水凝胶在近红外（NIR）照射下表现出优异的光热转换能力和生物相容性。此外，该水凝胶能够基于NIR照射实现药物的可控释放，最终提高抗菌活性。基于 和 实验，负载CIP的MXene/SA水凝胶（CIP-MX@Gel）加速了伤口愈合。总体而言，CIP-MX@Gel作为一种有效的伤口愈合材料具有优异的潜力。
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