Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China.
College of Basic Medical Sciences, Naval Medical University, Shanghai, 200433, PR China.
Talanta. 2024 Jan 1;266(Pt 2):125101. doi: 10.1016/j.talanta.2023.125101. Epub 2023 Aug 21.
Bacterial infections can significantly impair wound healing. Therefore, it is essential to develop wound dressings with high antimicrobial activity. Hydrogels are often used as wound dressings due to their excellent physicochemical properties. Herein, by cross linking sodium alginate (SA), agar (AG) with TiCT MXene and Zinc ions (Zn), a biosafe composite hydrogel (MSG-Zn) was developed for fast and efficient sterilization treatment. The excellent photothermal properties of TiCT MXene and the chemical antimicrobial activity of Zn enable synergistic photothermal therapy (PTT)/chemical therapy in NIR biowindow with reduced power density and improved antimicrobial efficiency. More importantly, the incorporation of Zn can enhance the effective contact between the hydrogel and bacteria, benefiting both photothermal and chemical antibacteria. In vitro antibacterial experiments showed that MSG-Zn has a broad-spectrum antibacterial effect against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). Cellular experiments showed that the hydrogel had excellent biocompatibility and the released Zn stimulated cell migration. In addition, the prepared MSG-Zn hydrogel has other advantages such as hydrophilic, high swelling, simple and low cost preparation, which meets the requirements of an economical wound dressing. This proposed work shows that this composite hydrogel MSG-Zn has great potential for practical antimicrobial wound dressing applications.
细菌感染会显著影响伤口愈合。因此，开发具有高抗菌活性的伤口敷料至关重要。水凝胶由于其优异的物理化学性质，常被用作伤口敷料。在此，通过交联海藻酸钠（SA）、琼脂（AG）与 TiCT MXene 和锌离子（Zn），开发了一种生物安全的复合水凝胶（MSG-Zn），用于快速高效的杀菌处理。TiCT MXene 的优异光热性能和 Zn 的化学抗菌活性使该水凝胶在近红外生物窗口中实现了协同光热治疗（PTT）/化学治疗，降低了功率密度，提高了抗菌效率。更重要的是，Zn 的掺入可以增强水凝胶与细菌的有效接触，有利于光热和化学抗菌。体外抗菌实验表明，MSG-Zn 对革兰氏阳性金黄色葡萄球菌（S. aureus）和革兰氏阴性大肠杆菌（E. coli）具有广谱抗菌作用。细胞实验表明，该水凝胶具有优异的生物相容性，释放的 Zn 刺激细胞迁移。此外，所制备的 MSG-Zn 水凝胶还具有亲水性、高溶胀性、制备简单且成本低等优点，符合经济型伤口敷料的要求。这项工作表明，这种复合水凝胶 MSG-Zn 在实际抗菌伤口敷料应用中具有巨大的潜力。
