Schmid P G, Schmid P G, Whiteis C A, Oda R P, Lund D D
Comput Methods Programs Biomed. 1986 Dec;23(3):283-96. doi: 10.1016/0169-2607(86)90063-5.
A set of three programs to calculate the turnover of biomolecules whose metabolism follows a steady-state precursor-product relationship and follows the open, single-compartment kinetics model has been written in MS-BASIC. The programs comprise a system for determining two values of turnover, before and after an intervention which may alter the turnover rate, in a single animal. The programs have been extensively tested in our laboratory for the determination of norepinephrine turnover under differing physiological and pharmacological conditions. The utility of the programs lies in their ability to readily adapt to turnover determinations for any substance whose metabolic pathway conforms to the model constraints. This includes the biogenic amine neurotransmitters, peptides and proteins, and many small biological molecules or pharmacological agents.
已用MS - BASIC编写了一组三个程序，用于计算生物分子的周转率。这些生物分子的代谢遵循稳态前体 - 产物关系，并符合开放的单室动力学模型。这些程序包括一个系统，用于确定在可能改变周转率的干预前后，单个动物体内生物分子周转率的两个值。这些程序已在我们实验室中进行了广泛测试，用于在不同生理和药理条件下测定去甲肾上腺素的周转率。这些程序的实用性在于它们能够轻松适用于任何代谢途径符合模型约束的物质的周转率测定。这包括生物胺神经递质、肽和蛋白质，以及许多小生物分子或药理剂。
