2023年佛罗里达州迈阿密一家注射器服务项目诊所中寻求医疗护理的注射吸毒者中赛拉嗪的流行情况。
Prevalence of xylazine among people who inject drugs seeking medical care at a syringe services program clinic: Miami, Florida, 2023.
作者信息
Hauschild Maia H, Warp Peyton V, Tookes Hansel E, Yakir Ella, Malhotra Bharat, Malik Subul, Owens Cyrus, Suarez Edward, Serota David P, Bartholomew Tyler S
机构信息
Department of Medical Education, University of Miami School of Medicine, USA.
Department of Medicine, University of Miami School of Medicine, USA.
出版信息
Drug Alcohol Depend Rep. 2023 Dec 5;9:100209. doi: 10.1016/j.dadr.2023.100209. eCollection 2023 Dec.
BACKGROUND
We aimed to report the preliminary xylazine prevalence among people who inject drugs (PWID) treated at a student-run free clinic in Miami, FL, USA and to identify characteristics associated with screening positive for xylazine.
METHODS
A retrospective chart review of 59 patients presenting to a syringe services program (SSP) clinic in was conducted between April 27th and August 17th, 2023. We measured presence of xylazine with rapid visual immunoassay strips on patient urine samples.
RESULTS
Xylazine was present in 55.9 % (33/59) of urine samples including 2 without detected opioids. Xylazine presence was significantly associated with unsheltered homelessness ( = 0.018), presence of wound(s) ( = 0.008), and testing positive for hepatitis C antibody ( = 0.014), fentanyl ( = 0.005) and MDMA ( = 0.002).
CONCLUSIONS
A high prevalence of xylazine in the Southeastern United States furthers evidence of the geographical spread of xylazine and rapidly evolving illicit drug supply. Widespread xylazine screening is urgently needed to inform people who inject drugs and to studyinterventions to minimize harms associated with xylazine.
背景
我们旨在报告在美国佛罗里达州迈阿密一家学生运营的免费诊所接受治疗的注射吸毒者（PWID）中赛拉嗪的初步流行情况，并确定与赛拉嗪筛查呈阳性相关的特征。
方法
对2023年4月27日至8月17日期间到一家注射器服务项目（SSP）诊所就诊的59名患者进行回顾性病历审查。我们使用快速视觉免疫分析试纸对患者尿液样本检测赛拉嗪的存在情况。
结果
55.9%（33/59）的尿液样本中存在赛拉嗪，其中2例未检测到阿片类药物。赛拉嗪的存在与无家可归（P = 0.018）、有伤口（P = 0.008）以及丙型肝炎抗体检测呈阳性（P = 0.014）、芬太尼（P = 0.005）和摇头丸（P = 0.002）显著相关。
结论
美国东南部赛拉嗪的高流行率进一步证明了赛拉嗪的地理传播和迅速演变的非法药物供应情况。迫切需要进行广泛的赛拉嗪筛查，以便为注射吸毒者提供信息，并研究干预措施以尽量减少与赛拉嗪相关的危害。
Zotero 插件