Oeding Jacob F, Graden Nathan R, Krych Aaron J, Sanchez-Sotelo Joaquin, Barlow Jonathan D, Camp Christopher L
School of Medicine, Mayo Clinic Alix School of Medicine, Rochester, Minnesota, U.S.A.
Oslo Sports Trauma Research Center, Norwegian School of Sport Sciences, Oslo, Norway.
Arthrosc Sports Med Rehabil. 2023 Dec 7;6(1):100836. doi: 10.1016/j.asmr.2023.100836. eCollection 2024 Feb.
To compare the cost-effectiveness of an initial trial of nonoperative treatment to that of early arthroscopic debridement for stable osteochondritis dissecans (OCD) lesions of the capitellum.
A Markov Chain Monte Carlo probabilistic model was developed to evaluate the outcomes and costs of 1,000 simulated patients undergoing nonoperative management versus early arthroscopic debridement for stable OCD lesions of the capitellum. Health utility values, treatment success rates, and transition probabilities were derived from the published literature. Costs were determined on the basis of the typical patient undergoing each treatment strategy at our institution. Outcome measures included costs, quality-adjusted life-years (QALYs), and the incremental cost-effectiveness ratio (ICER).
Mean total costs resulting from nonoperative management and early arthroscopic debridement were $5,330 and $21,672, respectively. On average, early arthroscopic debridement produced an additional 0.64 QALYS, resulting in an ICER of $25,245/QALY, which falls well below the widely accepted $50,000 willingness-to-pay (WTP) threshold. Overall, early arthroscopic debridement was determined to be the preferred cost-effective strategy in 69% of patients included in the microsimulation model.
Results of the Monte Carlo microsimulation and probabilistic sensitivity analysis demonstrated early arthroscopic debridement to be a cost-effective treatment strategy for the majority of stable OCD lesions of the capitellum. Although early arthroscopic debridement was associated with higher total costs, the increase in QALYS that resulted from early surgery was enough to justify the cost difference based on an ICER substantially below the $50,000 WTP threshold.
Level III, economic computer simulation model.
比较对稳定型肱骨小头剥脱性骨软骨炎(OCD)病变进行非手术治疗初始试验与早期关节镜下清创术的成本效益。
建立马尔可夫链蒙特卡罗概率模型,以评估1000例接受非手术治疗与早期关节镜下清创术治疗稳定型肱骨小头OCD病变的模拟患者的结局和成本。健康效用值、治疗成功率和转移概率来自已发表的文献。成本根据本机构接受每种治疗策略的典型患者确定。结局指标包括成本、质量调整生命年(QALY)和增量成本效益比(ICER)。
非手术治疗和早期关节镜下清创术产生的平均总成本分别为5330美元和21672美元。平均而言,早期关节镜下清创术额外产生0.64个QALY,ICER为25245美元/QALY,远低于广泛接受的50000美元支付意愿(WTP)阈值。总体而言,在微观模拟模型纳入的69%的患者中,早期关节镜下清创术被确定为首选的成本效益策略。
蒙特卡罗微观模拟和概率敏感性分析结果表明,早期关节镜下清创术是大多数稳定型肱骨小头OCD病变的一种具有成本效益的治疗策略。虽然早期关节镜下清创术的总成本较高,但早期手术带来的QALY增加足以证明基于ICER大幅低于50000美元WTP阈值的成本差异是合理的。
三级,经济计算机模拟模型。