Catolico M M, Campbell S, Jones W N, Logan J L
Drug Intell Clin Pharm. 1987 Jan;21(1 Pt 1):46-9. doi: 10.1177/10600280870211p107.
The rebound in gentamicin serum concentration following hemodialysis was studied in six patients with chronic renal failure. The patients were not infected at the time of the study and received a single dose of gentamicin 2 mg/kg before hemodialysis. Serum samples were obtained immediately after dialysis and at 0.5, 1, 2, and 3 hours following hemodialysis. The average increases in gentamicin serum concentrations were 3.6 percent at 0.5 hour, 12.6 percent at 1 hour, and 6.6 percent at 2 hours. An average decline of 4.2 percent occurred at three hours. Only the increase seen at one hour was significantly different from the gentamicin serum concentration immediately following hemodialysis. This rebound was of small magnitude, though, and may not be clinically significant.
对6例慢性肾衰竭患者进行了血液透析后庆大霉素血清浓度反弹的研究。研究时患者未感染，在血液透析前接受单剂量2mg/kg的庆大霉素。透析结束后立即以及透析后0.5、1、2和3小时采集血清样本。庆大霉素血清浓度平均升高幅度在0.5小时为3.6%，1小时为12.6%，2小时为6.6%。3小时时平均下降4.2%。只有1小时时的升高与血液透析刚结束时的庆大霉素血清浓度有显著差异。不过，这种反弹幅度较小，可能无临床意义。
