Bauer L A
Ther Drug Monit. 1982;4(1):99-101. doi: 10.1097/00007691-198204000-00015.
After observing the phenomenon clinically, seven post-hemodialysis patients were studied for a rebound effect of gentamicin levels. Serum gentamicin levels were obtained immediately after dialysis and 1 hr postdialysis. An average 25.7% rebound occurred in the serum levels. A slow redistribution of gentamicin out of tissue into the serum is the probable mechanism. This data suggests that a short time period should be allowed before postdialysis levels are obtained to determine gentamicin replacement doses.
在临床观察到该现象后，对7名血液透析后患者的庆大霉素水平的反弹效应进行了研究。在透析结束后立即及透析后1小时获取血清庆大霉素水平。血清水平平均出现了25.7%的反弹。庆大霉素从组织缓慢重新分布到血清中可能是其机制。该数据表明，在获取透析后水平以确定庆大霉素替代剂量之前，应留出一段短时间。
