Guilford J, Eugere E, Mitra G, Ghosh D
Drug Chem Toxicol. 1986;9(3-4):239-52. doi: 10.3109/01480548608998278.
The possibility that lead could affect the metabolism of the insecticide 1,1-dichloro-2, 2-bis(p-chlorophenyl)ethane, DDD, was examined by studies of the effects of chronic oral Pb treatment on DDD conversion to 2,2-bis(p-chlorophenyl)acetic acid, DDA. Rats were given either distilled deionized water or 0.05, 0.58, 17 or 352 ppm Pb solutions as drinking water. Systolic blood pressure and body weight were measured weekly. Rats drinking 352 ppm lead chloride manifested a statistically significant increase in blood pressure. Rats drinking 352 ppm and 17 ppm lead chloride showed a significant decrease in the rate of weight gain compared to controls. All groups showed an increase in the excretion of total DDA compared to controls.
通过研究慢性口服铅处理对杀虫剂1,1-二氯-2,2-双（对氯苯基）乙烷（DDD）转化为2,2-双（对氯苯基）乙酸（DDA）的影响，来检验铅是否会影响该杀虫剂的代谢。给大鼠饮用蒸馏水或浓度为0.05、0.58、17或352 ppm的铅溶液。每周测量收缩压和体重。饮用352 ppm氯化铅的大鼠血压有统计学意义的显著升高。与对照组相比，饮用352 ppm和17 ppm氯化铅的大鼠体重增加率显著下降。与对照组相比，所有组的总DDA排泄量均增加。
