[Effect of a delayed type hypersensitivity reaction on the cytotoxic activity of macrophages, natural and antibody-dependent killer cells].

It is established that preparations which cause the delayed type hypersensitivity reaction (DTHR), such as old tuberculine of Koch (OTK) and staphylococcal phagolysate (SPL), being administered to mice sensibilized preliminary by BCG vaccine or staphylococcus, lead to considerable reinforcement of natural cytotoxicity of peritoneal macrophages and natural killer cells (NK-cells) and killer cells (K-cells) to a small extent. In the course of DTHR there is an increase in the ability of effector cells to bind with target ones (especially in macrophages) as well as in the quantity of cytolytic effectors. The cultural medium from macrophages of mice with DTHR which have internalized the opsonized particles of zymosan or have interacted with target cells P815, intensifies the activity of NK- and K-cells while the same medium from macrophages of intact animals possesses a depressed action on the NK- and K-cells activity. The cultural medium from spleen lymphocytes which mediated the NK- and K-cells activity of the intact animals as well as mice with DTHR does not influence cytotoxicity of macrophages.