分析中国医护人员中 HIV 药物预防服务的传递情况：一项横断面研究。

Analysis of HIV drug prophylaxis services cascade in healthcare workers: a cross-sectional study in China.

机构信息

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Chinese Association of STD&AIDS Prevention and Control, Beijing, China.

出版信息

BMC Infect Dis. 2024 Jan 2;24(1):4. doi: 10.1186/s12879-023-08873-x.

DOI:10.1186/s12879-023-08873-x

PMID:38166686

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10759606/

Abstract

BACKGROUND

Human immunodeficiency virus (HIV) drug prophylaxis, including post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), has not yet been generally recognized and accepted by the whole society in China, and the utilization coverage among high-risk populations is low. Healthcare workers (HCWs) are important to the promotion and implementation of HIV drug prophylaxis strategy. This study analyzed the HIV drug prophylaxis services cascade (knowledge, attitude, and service) in HCWs, and explored the correlations between PEP and PrEP.

METHODS

A cross-sectional study was conducted among 1066 HCWs in 20 designated hospitals for HIV antiretroviral therapy in 20 cities in China. We collected information on participants' essential characteristics, HIV drug prophylaxis services cascade (knowledge, attitude, and service) and so on. The Chi-square test was used to analyse whether the differences and correlations between categorical variables were statistically significant, and Pearson contingency coefficient was used to analyse the strength of correlations. Multivariable logistic regression was used to analyse associated factors.

RESULTS

Among three stages of HIV drug prophylaxis services cascade, a high percentage of 1066 participants had knowledge of HIV drug prophylaxis (PEP: 78.2%, PrEP: 80.0%). Of them, almost all had supportive attitudes towards HIV drug prophylaxis (PEP: 99.6%, PrEP: 98.6%). Only about half of them would provide HIV drug prophylaxis services (PEP: 53.5%, PrEP: 48.5%). There were positive correlations between knowledge of PEP and PrEP (r = 0.292), between attitudes toward PEP and PrEP (r = 0.325), and between provision of PEP services and PrEP services (r = 0.555) in HCWs.

CONCLUSIONS

There was a positive correlation between PEP and PrEP in HCWs. At the stage of providing HIV drug prophylaxis services, training, advocacy and education for HCWs, should be targeted and also combine PEP and PrEP to maximize the effects, so as to improve the enthusiasm of HCWs to provide HIV drug prophylaxis services.

摘要

背景

人类免疫缺陷病毒（HIV）药物预防，包括暴露后预防（PEP）和暴露前预防（PrEP），尚未在中国得到全社会的普遍认可和接受，高危人群的利用覆盖率较低。医护人员（HCWs）对 HIV 药物预防策略的推广和实施至关重要。本研究分析了 HCWs 中 HIV 药物预防服务级联（知识、态度和服务），并探讨了 PEP 和 PrEP 之间的相关性。

方法

采用横断面研究，在中国 20 个城市的 20 家指定 HIV 抗逆转录病毒治疗医院中，对 1066 名 HCWs 进行调查。收集参与者的基本特征、HIV 药物预防服务级联（知识、态度和服务）等信息。采用卡方检验分析分类变量的差异和相关性是否有统计学意义，采用 Pearson 列联系数分析相关性的强弱。采用多变量 logistic 回归分析相关因素。

结果

在 HIV 药物预防服务级联的三个阶段中，1066 名参与者对 HIV 药物预防的知识（PEP：78.2%，PrEP：80.0%）比例较高。其中，几乎所有人对 HIV 药物预防都持支持态度（PEP：99.6%，PrEP：98.6%）。只有约一半的人会提供 HIV 药物预防服务（PEP：53.5%，PrEP：48.5%）。HCWs 中 PEP 和 PrEP 的知识（r=0.292）、PEP 和 PrEP 的态度（r=0.325）以及 PEP 服务和 PrEP 服务的提供（r=0.555）之间存在正相关。