乳腺癌女性化疗前后的身体和自主神经功能：一项病例对照研究。
Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study.
作者信息
Sousa Bruna Lorena Soares Cavalcante, Dos Santos Rosa Thiago, Silvino Valmir Oliveira, Barros Esmeralda Maria Lustosa, de Luca Corrêa Hugo, do Prado Danilo Marcelo Leite, Veras-Silva Acácio Salvador, de Souza Mariana Duarte, de Lima Carlos Eduardo Batista, de Oliveira Luciano Fonseca Lemos, Dos Santos Marcos Antonio Pereira
机构信息
Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, PI, Brazil.
Rehabilitation Sciences Program, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
BMC Sports Sci Med Rehabil. 2024 Jan 2;16(1):5. doi: 10.1186/s13102-023-00797-y.
BACKGROUND
Breast cancer (BC) is one of the most incident types of cancer among women in the world. Although chemotherapy is an effective way to treat several types of cancer, it may also cause serious complications, including cardiotoxicity. This study aimed to identify the impact of chemotherapy on functional capacity, muscle strength and autonomic function.
METHODS
Ten breast cancer patients in therapeutic follow-up (TG) and ten women without comorbidities (CG) participated in the study (46±8.87 years old). Both groups were evaluated at two time points, before and 20 weeks after the start of chemotherapy. Functional capacity and muscle strength were assessed by 6-minute walk test (6MWT) and handgrip test, respectively. Autonomic function was assessed by heart rate variability analysis.
RESULTS
TG presented greater reductions in the handgrip test for the non-dominant hand (TG ↓15.2%; CG: ↑1.1%, p<0.05) compared to GC. However, no significant differences were found regarding VOmax (p>0.05) and 6MWT total distance (p>0.05). Regarding the heart rate variability variables before and after follow-up period, rMSSD (CG= 39.15±37.66; TG= 14.89±8.28, p= 0.01) and SDNN (CG= 55.77±40.03; TG= 26.30±10.37, p= 0.02) showed effect in the group and time interaction, whereas the LF/HF ratio presented significant difference only in the time analysis (CG= 2.24±2.30; TG= 2.84±1.82, p= 0.04).
CONCLUSION
Chemotherapy used in the treatment of breast cancer patients resulted in decreased muscle strength and autonomic imbalance. The data suggests that chemotherapy may carry the risk of developing cardiovascular disease.
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背景
乳腺癌（BC）是全球女性中发病率最高的癌症类型之一。尽管化疗是治疗多种癌症的有效方法，但它也可能导致严重并发症，包括心脏毒性。本研究旨在确定化疗对功能能力、肌肉力量和自主神经功能的影响。
方法
十名处于治疗随访期（TG）的乳腺癌患者和十名无合并症的女性（CG）参与了本研究（年龄46±8.87岁）。两组均在两个时间点进行评估，即化疗开始前和开始后20周。功能能力和肌肉力量分别通过6分钟步行试验（6MWT）和握力试验进行评估。自主神经功能通过心率变异性分析进行评估。
结果
与CG组相比，TG组非优势手握力试验的下降幅度更大（TG组下降15.2%；CG组上升1.1%，p<0.05）。然而，在最大摄氧量（p>0.05）和6MWT总距离方面未发现显著差异（p>0.05）。关于随访前后的心率变异性变量，相邻RR间期差值的均方根（CG=39.15±37.66；TG=14.89±8.28，p=0.01）和标准差（CG=55.77±40.03；TG=26.30±10.37，p=0.02）在组间和时间交互作用方面有影响，而低频/高频比值仅在时间分析中有显著差异（CG=2.24±2.30；TG=2.84±1.82，p=0.04）。
结论
用于治疗乳腺癌患者的化疗导致肌肉力量下降和自主神经失衡。数据表明化疗可能存在发生心血管疾病的风险。
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