Keränen T, Partanen V S, Koivisto K, Tokola O, Neuvonen P J, Riekkinen P J
Epilepsia. 1987 Mar-Apr;28(2):133-7. doi: 10.1111/j.1528-1157.1987.tb03638.x.
Taltrimide is a lipophilic taurine derivative with definitive anticonvulsive effects in experimental epilepsy models. In this study, taltrimide was administered for 6 days, and the effects of the treatment on photoconvulsive response in EEG in eight epileptic patients were evaluated. Discharges provoked by intermittent photic stimulation (IPS) were increased by greater than 50% in four patients after taltrimide treatment. Only one patient had reduction of sensitivity. There was only a slight change in discharges after hyperventilation and no change in spontaneous paroxysms. The effects of taltrimide on photosensitivity appear to be rather specific. The study does not reveal anticonvulsive effects of taltrimide in humans.
他林米特是一种亲脂性牛磺酸衍生物，在实验性癫痫模型中具有明确的抗惊厥作用。在本研究中，给予他林米特6天，并评估了该治疗对8例癫痫患者脑电图光惊厥反应的影响。他林米特治疗后，4例患者因间歇性光刺激（IPS）诱发的放电增加超过50%。只有1例患者敏感性降低。过度换气后放电仅有轻微变化，自发性发作无变化。他林米特对光敏感性的影响似乎相当特异。该研究未揭示他林米特对人类的抗惊厥作用。
