Drouard Gabin, Wang Zhiyang, Heikkinen Aino, Foraster Maria, Julvez Jordi, Kanninen Katja M, van Kamp Irene, Pirinen Matti, Ollikainen Miina, Kaprio Jaakko
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain.
medRxiv. 2023 Dec 14:2023.12.12.23299868. doi: 10.1101/2023.12.12.23299868.
Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.
双胞胎之间生活方式的差异是否反映在其内部或外部暴露组特征的差异上，在很大程度上仍未得到充分探索。因此，我们调查了生活方式的同对内差异是否与四个领域的暴露组特征同对内差异相关：外部暴露组、蛋白质组、代谢组和表观遗传年龄加速（EAA）。对于每个领域，我们使用高斯相似度评估了多达257对年轻成年同性双胞胎（54%为同卵双胞胎）的双胞胎特征相似度。我们还测试了一个领域的相似度是否会转化为另一个领域的更高相似度。结果表明，双胞胎暴露组特征的相似度较低与他们的行为和物质使用方面的更大差异有关。在过度饮酒行为和外部暴露组之间发现了最强的关联。总体而言，我们的研究展示了社会行为尤其是物质使用如何在控制家族混杂因素的同时与内部和外部暴露组相联系。
