Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain.
Sci Rep. 2024 Sep 11;14(1):21261. doi: 10.1038/s41598-024-72354-7.
Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.
双胞胎之间的生活方式差异是否反映在他们内部或外部暴露组谱的差异上，这在很大程度上仍未得到充分探索。因此，我们研究了生活方式的个体内差异是否与四个领域的暴露组谱的个体内差异相关：外部暴露组谱、蛋白质组谱、代谢组谱和表观遗传年龄加速（EAA）。对于每个领域，我们使用多达 257 对年轻成年同性别双胞胎（54% 为同卵双胞胎）的高斯相似度评估同卵双胞胎的相似性。我们还测试了一个领域的相似性是否转化为另一个领域的更大相似性。结果表明，双胞胎暴露组谱的相似程度较低与他们的行为和物质使用差异较大有关。过度饮酒行为与外部暴露组谱之间的关联最强。总的来说，我们的研究表明，社会行为，尤其是物质使用与内部和外部暴露组谱之间存在联系，同时控制了家族混杂因素。
