Hourani S M, Loizou G D, Cusack N J
Eur J Pharmacol. 1986 Nov 12;131(1):99-103. doi: 10.1016/0014-2999(86)90521-2.
The pharmacological effects of ATP and of two of its analogues, AMP-PCP and L-AMP-PCP, were investigated in various isolated smooth muscle preparations. In the guinea-pig vas deferens, the rat portal vein and the rat anococcygeus the nucleotides all caused contraction, and the order of potency was L-AMP-PCP greater than AMP-PCP greater than ATP. In the guinea-pig field-stimulated ileal longitudinal muscle the nucleotides all inhibited the contractions, and the order of potency was ATP greater than AMP-PCP greater than L-AMP-PCP. In the guinea-pig thoracic aorta ATP and AMP-PCP caused relaxations, ATP being more potent than AMP-PCP, and L-AMP-PCP caused contractions. These results are consistent with the suggestion that the ATP receptors mediating contraction of smooth muscle are different from those mediating relaxation, and show that L-AMP-PCP is a potent, specific agonist at excitatory ATP receptors.
研究了ATP及其两种类似物AMP-PCP和L-AMP-PCP在各种离体平滑肌制剂中的药理作用。在豚鼠输精管、大鼠门静脉和大鼠肛门尾骨肌中，这些核苷酸均引起收缩，其效力顺序为L-AMP-PCP＞AMP-PCP＞ATP。在豚鼠场刺激回肠纵肌中，这些核苷酸均抑制收缩，其效力顺序为ATP＞AMP-PCP＞L-AMP-PCP。在豚鼠胸主动脉中，ATP和AMP-PCP引起舒张，ATP比AMP-PCP更有效，而L-AMP-PCP引起收缩。这些结果与以下观点一致，即介导平滑肌收缩的ATP受体与介导舒张的受体不同，并表明L-AMP-PCP是兴奋性ATP受体的一种有效、特异性激动剂。
