Lee Yun Haeng, Kuk Myeong Uk, So Moon Kyoung, Park Hyon Jin, Song Eun Seon, Park Jiho, Yoon Jee Hee, Kwon Hyung Wook, Choi Jaehyuk, Park Joon Tae
Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
Convergence Research Center for Insect Vectors, Incheon National University, Incheon 22012, Korea.
J Cancer. 2024 Jan 1;15(2):309-316. doi: 10.7150/jca.89059. eCollection 2024.
Cancer cells are characterized by apoptosis evasion and uncontrolled cell cycle progression. To combat these characteristics, efforts have been made to find novel natural-source anticancer compounds. The aim of this work is to find new anticancer compounds in () mycelial culture extracts. mycelium was cultured on four individual media (DYB, MEB, MYB, and PDB) and four extracts were generated from the mycelium culture media. Extracts of mycelium cultured in MEB medium (pu-MEB) significantly reduced cancer cell growth by triggering apoptosis and S phase arrest. Furthermore, the anticancer effects of pu-MEB were not confined to one type of cancer. Taken together, our results confirmed that mycelia cultured in MEB medium produce metabolites that exhibit anticancer properties. Development of an optimal medium for mycelium through optimization of medium components will enable mycelium to produce metabolites with more anticancer efficacy.
癌细胞的特征是逃避细胞凋亡和细胞周期进展不受控制。为了对抗这些特征，人们一直在努力寻找新型天然来源的抗癌化合物。这项工作的目的是在（）菌丝体培养提取物中寻找新的抗癌化合物。将（）菌丝体在四种单独的培养基（DYB、MEB、MYB和PDB）上培养，并从菌丝体培养基中制备了四种提取物。在MEB培养基（pu-MEB）中培养的（）菌丝体提取物通过触发细胞凋亡和S期阻滞显著降低了癌细胞的生长。此外，pu-MEB的抗癌作用并不局限于一种癌症类型。综上所述，我们的结果证实，在MEB培养基中培养的（）菌丝体产生具有抗癌特性的代谢物。通过优化培养基成分开发适合（）菌丝体生长的最佳培养基，将使（）菌丝体产生具有更高抗癌功效的代谢物。
