人精浆中降钙素和类降钙素基因相关肽样免疫反应性

Calcitonin- and katacalcin-like immunoreactivity in human seminal plasma.

作者信息

Maier U, Woloszczuk W, Schuh H, Zechner O

出版信息

Exp Clin Endocrinol. 1986 Nov;88(1):89-94. doi: 10.1055/s-0029-1210580.

Abstract

iCT was determined in 74 patients by direct RIA. A highly significant increase (371 pg/ml) compared with normal serum concentration (100 pg/ml) was observed. There was no correlation between iCT concentration and ejaculate parameters. In addition monomeric bioactive CT and from the same RNA derived KT were determined from a seminal plasma pool gathered from 25 patients. The measured amounts were similar to those found in plasma. Monomeric CT or KT is not responsible for high amounts of iCT in seminal plasma found by direct radioimmunoassay. High amounts of iCT or iKT are due to two heterogenous peptides with greater molecular mass but have no influence on fertility.

摘要

通过直接放射免疫分析法对74例患者的完整甲状旁腺素（iCT）进行了测定。与正常血清浓度（100 pg/ml）相比，观察到有高度显著的升高（371 pg/ml）。iCT浓度与射精参数之间无相关性。此外，从25例患者采集的精浆池中测定了单体生物活性降钙素（CT）以及来自相同RNA的中段甲状旁腺素（KT）。所测含量与血浆中的含量相似。直接放射免疫分析法在精浆中发现的大量iCT并非由单体CT或KT所致。大量的iCT或iKT是由两种分子量更大的异源肽引起的，但对生育能力没有影响。