Szokol M, Soltész M B, Nagy A, Lengyel Z, Gomba S
Exp Pathol. 1986;30(4):233-42. doi: 10.1016/s0232-1513(86)80082-2.
Urinary proteins were studied by quantitative and electrophoretic methods in 6-month-old spontaneously hypertensive rats and normotensive controls. Protein analysis was carried out before and after adrenalectomy and during gluco- or mineralocorticoid treatment. Urinary protein excretion was significantly diminished after adrenalectomy both in the hypertensive and control groups. The original level of protein excretion was restored only by glycocorticoid treatment. Normal or pathologic electrophoretic pattern of urinary proteins was not influenced by the experimental procedure. Moderately non-selective glomerular proteinuria persisted in the spontaneously hypertensive rats referring to a definitely damaged glomerular barrier. One protein fraction of about 130,000 dalton molecular weight disappeared from the urine of hypertensive animals after adrenalectomy and reappeared after glucocorticoid treatment only. This fraction probably represents the dimeric form of albumin. Quantitative changes of urinary protein excretion can be explained by haemodynamic factors.
采用定量和电泳方法，对6月龄自发性高血压大鼠和正常血压对照大鼠的尿蛋白进行了研究。在肾上腺切除术前、术后以及糖皮质激素或盐皮质激素治疗期间进行了蛋白质分析。肾上腺切除术后，高血压组和对照组的尿蛋白排泄均显著减少。仅通过糖皮质激素治疗才能恢复原来的蛋白排泄水平。尿蛋白的正常或病理电泳模式不受实验过程影响。自发性高血压大鼠持续存在中度非选择性肾小球蛋白尿，提示肾小球屏障存在明确损伤。肾上腺切除术后，高血压动物尿液中一种分子量约为130,000道尔顿的蛋白组分消失，仅在糖皮质激素治疗后重新出现。该组分可能代表白蛋白的二聚体形式。尿蛋白排泄的定量变化可用血流动力学因素来解释。
