Kim Jung-Kyeom, Park Sang-Won, Lee Suk-Hee, Kasani Payam Hosseinzadeh, Byeon Gi Hwan, Kim Yeshin, Jang Jae-Won, Lee Seo-Young
Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.
Department of Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
J Clin Neurol. 2024 Mar;20(2):208-213. doi: 10.3988/jcn.2022.0257. Epub 2024 Jan 1.
The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.
We reconstructed a population-based matched cohort from the National Health Insurance Service-Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.
Overall 53,776 subjects with lower-body fractures were identified during 2006-2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lower-body fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49-1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14-1.23).
These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.
多项观察性研究已表明身体活动与痴呆症之间存在关联。我们旨在确定下肢骨折老年人患痴呆症的风险。
我们利用韩国国民健康保险服务高级队列数据集重建了一个基于人群的匹配队列，该数据集涵盖了511,953名医疗保险参保人。
在2006年至2012年期间共识别出53,776名下肢骨折患者，并为每名骨折患者按性别、年龄和距索引日期的年份随机匹配了三组对照组。从2008年到2015年，有3,573名（6.6%）下肢骨折患者和7,987名（4.9%）无下肢骨折患者患痴呆症。与上肢骨折（调整后风险比[aHR]=1.19，95%置信区间[CI]=1.14 - 1.23）相比，下肢骨折与随后的痴呆症诊断独立相关，调整后风险比更高（aHR=1.55，95% CI=1.49 - 1.62）。
这些结果支持身体活动对痴呆症的保护作用，并强调了促进老年人预防骨折的重要性。
