孕期坚持得舒饮食和地中海饮食与孕妇C反应蛋白水平的相关性。

Associations of adherence to the DASH diet and Mediterranean diet with maternal c-reactive protein levels during pregnancy.

作者信息

van der Pligt Paige F, Ebrahimi Sara, Kuswara Konsita, Abbott Gavin R, McNaughton Sarah A, Islam Sheikh Mohammed Shariful, Ellery Stacey J

机构信息

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, 3220, Australia; Department of Nutrition, Western Health, Footscray, Australia.

School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria 3220, Australia; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

出版信息

Nutr Metab Cardiovasc Dis. 2024 Mar;34(3):672-680. doi: 10.1016/j.numecd.2023.11.001. Epub 2023 Nov 7.

DOI:10.1016/j.numecd.2023.11.001

PMID:38172005

Abstract

BACKGROUND AND AIMS

Elevated C-reactive protein (CRP) during pregnancy, a marker of inflammation, is associated with adverse outcomes. Better understanding the relationship between CRP and modifiable factors, including diet, is essential to assist early pregnancy lifestyle interventions. The aim of this study was to assess the relationship between adherence to the Dietary Approaches to Stop Hypertension diet (DASH-diet) and the Mediterranean diet (MED-diet) during pregnancy with maternal plasma CRP in early and late pregnancy.

METHODS AND RESULTS

Secondary analysis of the Creatine and Pregnancy Outcomes (CPO) study was undertaken. Women (n = 215) attending antenatal clinics through Monash Health, Melbourne were recruited at 10-20 weeks gestation. Medical history and blood samples were collected at 5 antenatal visits. Adapted DASH-diet and MED-diet scores were calculated from Food Frequency Questionnaires completed at early ([mean ± SD]) (15 ± 3 weeks) and late (36 ± 1 week) pregnancy. CRP was measured in maternal plasma samples collected at the same time points. Adjusted linear regression models assessed associations of early-pregnancy DASH and MED-diet scores with early and late pregnancy plasma CRP. There were no statistically significant changes in DASH-diet score from early (23.5 ± 4.8) to late (23.5 ± 5.2) pregnancy (p = 0.97) or MED-diet score from early (3.99 ± 1.6) to late pregnancy (4.08 ± 1.8) (p = 0.41). At early-pregnancy, there was an inverse relationship between DASH-diet scores and MED-diet scores with plasma CRP; (β = -0.04 [95%CI = -0.07, -0.00], p = 0.044), (β = -0.12 [95%CI = -0.21, -0.02], p = 0.023).

CONCLUSION

Adherence to the DASH-diet and MED-diet during early pregnancy may be beneficial in reducing inflammation. Assessment of maternal dietary patterns may assist development of preventive strategies, including dietary modification, to optimise maternal cardiometabolic health in pregnancy.

摘要

背景与目的

孕期C反应蛋白（CRP）升高是一种炎症标志物，与不良结局相关。更好地理解CRP与包括饮食在内的可改变因素之间的关系，对于协助孕期早期生活方式干预至关重要。本研究的目的是评估孕期坚持终止高血压膳食方法（DASH饮食）和地中海饮食（MED饮食）与孕早期和孕晚期孕妇血浆CRP之间的关系。

方法与结果

对肌酸与妊娠结局（CPO）研究进行了二次分析。招募了通过墨尔本莫纳什健康中心产前诊所就诊的女性（n = 215），妊娠10 - 20周。在5次产前检查时收集病史和血样。根据在孕早期（[均值±标准差]）（15 ± 3周）和孕晚期（36 ± 1周）完成的食物频率问卷计算调整后的DASH饮食和MED饮食得分。在相同时间点采集的孕妇血浆样本中测量CRP。调整后的线性回归模型评估孕早期DASH和MED饮食得分与孕早期和孕晚期血浆CRP的关联。从孕早期（23.5 ± 4.8）到孕晚期（23.5 ± 5.2），DASH饮食得分无统计学显著变化（p = 0.97）；从孕早期（3.99 ± 1.6）到孕晚期（4.08 ± 1.8），MED饮食得分也无统计学显著变化（p = 0.41）。在孕早期，DASH饮食得分和MED饮食得分与血浆CRP呈负相关；（β = -0.04 [95%CI = -0.07, -0.00]，p = 0.044），（β = -0.12 [95%CI = -0.21, -0.02]，p = 0.023）。