Orosco M, Duche J C, Rybarczyk M C, Rouch C, Cohen Y, Jacquot C
Gen Pharmacol. 1986;17(6):665-9. doi: 10.1016/0306-3623(86)90298-3.
The interactions between cholecystokinin (CCK) and brain monoamines have been investigated. The data found in the literature are quite dissimilar. Several reasons for these disparities have been suggested. We have sought to test some of them, such as the strain of rat, the nutritional state (by the use of two models of obesity), the length of the peptide (CCK 8 and CCK 33), the route of administration (i.p. and i.c.v.) and the time of sacrifice. We indeed found all these experimental conditions to be the cause of differential effects on brain monoamines and metabolites. However, by repeating the same experiments several times, we did not always obtain the same variations, even under the same conditions. In addition to the different parameters tested, another source of variability exists, possibly due to the molecule itself or to seasonal variations.
人们已经对胆囊收缩素（CCK）与脑单胺之间的相互作用进行了研究。文献中发现的数据差异很大。针对这些差异提出了几个原因。我们试图对其中一些原因进行测试，比如大鼠的品系、营养状态（通过使用两种肥胖模型）、肽的长度（CCK 8和CCK 33）、给药途径（腹腔注射和脑室内注射）以及处死时间。我们确实发现所有这些实验条件都是对脑单胺和代谢物产生不同影响的原因。然而，通过多次重复相同的实验，即使在相同条件下，我们也并非总能得到相同的变化。除了所测试的不同参数外，还存在另一个变异性来源，这可能是由于分子本身或季节变化所致。
