Orosco M, Rybarczyk M C, Rouch C, Cohen Y, Jacquot C
Neuropharmacology. 1987 Jun;26(6):575-9. doi: 10.1016/0028-3908(87)90150-x.
Cholecystokinin (CCK) and Bombesin (BBS) are two neuropeptides which induce changes in monoamines in the brain after peripheral administration. A vagal mediation of these effects was investigated since the satiety responses to both peptides are affected differently by vagotomy. This work was performed on genetically obese and lean Zucker rats and on "cafeteria-fed" and lean Sprague-Dawley rats as the effects of the peptides are dissimilar in these different groups. Vagotomy either inhibited or potentiated the peptide-induced effects, or created new variations. With CCK, the inhibition occurred mainly in the serotonergic system and in the Zucker strain, while new effects appeared in the dopaminergic system of lean rats of both strains. With bombesin, vagotomy inhibited the effects in the dopaminergic system in all lean rats, while new effects were observed in the serotonergic system in the Zucker strain. These data enable the differentiation of the mechanisms of action of both peptides and their selective effects, according to the strain of rat and the presence or absence of obesity.
胆囊收缩素（CCK）和蛙皮素（BBS）是两种神经肽，外周给药后可引起大脑中单胺类物质的变化。由于迷走神经切断术对这两种肽的饱腹感反应有不同影响，因此对这些作用的迷走神经介导进行了研究。这项研究在遗传性肥胖和瘦型 Zucker 大鼠以及“自助餐喂养”和瘦型 Sprague-Dawley 大鼠上进行，因为这些肽在不同组中的作用不同。迷走神经切断术要么抑制要么增强肽诱导的作用，或者产生新的变化。对于 CCK，抑制主要发生在血清素能系统和 Zucker 品系中，而在两种品系的瘦型大鼠的多巴胺能系统中出现了新的作用。对于蛙皮素，迷走神经切断术在所有瘦型大鼠的多巴胺能系统中抑制了作用，而在 Zucker 品系的血清素能系统中观察到了新的作用。这些数据能够根据大鼠品系以及肥胖的存在与否，区分这两种肽的作用机制及其选择性作用。
