Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Cell Rep. 2024 Jan 23;43(1):113657. doi: 10.1016/j.celrep.2023.113657. Epub 2024 Jan 3.
Environmental factors influence an organism's reproductive ability by regulating germline development and physiology. While the reproductive adaptations in response to extrinsic stress cues offer fitness and survival advantages to individuals, the mechanistic understanding of these modifications remains unclear. Here, we find that parasitoid wasps' stress signaling regulates Drosophila melanogaster oogenesis. We show that fruit flies dwelling in the wasp-infested area elevate their fecundity, and the observed reproductive response is specific to Pachycrepoideus sp., a pupal parasitoid wasp. Pachycrepoideus-specific olfactory and visual cues recruit the signaling pathways that promote germline stem cell proliferation and accelerate follicle development, increasing egg production in Drosophila females. Downregulation of signaling engaged in oocyte development by shifting flies to a non-wasp-infested environment increases apoptosis of the developing follicles. Thus, this study establishes host germline responsiveness to parasitoid-specific signals and supports a predator strategy to increase hosts for infection.
环境因素通过调节生殖细胞发育和生理机能来影响生物的生殖能力。虽然针对外在压力信号的生殖适应性为个体提供了适应和生存优势，但这些变化的机制尚不清楚。在这里，我们发现寄生蜂的应激信号调控了黑腹果蝇的卵子发生。我们发现，生活在寄生蜂出没地区的果蝇提高了它们的繁殖力，而观察到的生殖反应是针对 Pachycrepoideus sp.（一种蛹寄生蜂）特有的。Pachycrepoideus 特异性的嗅觉和视觉线索募集了促进生殖干细胞增殖和加速滤泡发育的信号通路，从而增加了果蝇雌性的产卵量。通过将果蝇转移到没有寄生蜂出没的环境中，下调参与卵母细胞发育的信号通路会增加发育中的滤泡的细胞凋亡。因此，这项研究确立了宿主生殖细胞对寄生蜂特异性信号的反应性，并支持了一种增加宿主感染的捕食者策略。
