College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, China.
College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China.
Ecotoxicol Environ Saf. 2024 Jan 15;270:115907. doi: 10.1016/j.ecoenv.2023.115907. Epub 2024 Jan 4.
Fluoride has strong electronegativity and exposes diversely in nature. Water fluoridation is the most pervasive form of occurrence, representing a significant threat to human health. In this study, we investigate the morphometric and physiological alterations triggered by fluoride stimulation during the embryogenesis of zebrafish and reveal its putative effects of stage- and/or dose-dependent. Fluoride exhibits potent biological activity and can be extensively absorbed by the yolk sac, exerting significant effects on the development of multiple organs. This is primarily manifested as restricted nutrient utilization and elevated levels of lipid peroxidation, further leading to the accumulation of superoxide in the yolk sac, liver, and intestines. Moreover, pericardial edema exerts pressure on the brain and eye development, resulting in spinal curvature and reduced body length. Besides, acute fluoride exposure with varying concentrations has led to diverse teratogenic outcomes. A low dose of water fluoridation tends to induce abnormal development of the embryonic yolk sac, while vascular malformation is widely observed in all fluoride-treated groups. The effect of fluoride exposure on blood circulation is universally present, even in zebrafish larvae that do not exhibit obvious deformities. Their swimming behavior is also affected by water fluoridation, resulting in reduced activity and delayed reactions. In conclusion, this study provides valuable insights into the monitoring of environmental quality related to water fluoridation and disease prevention.
氟具有很强的电负性，在自然界中广泛存在。水氟化是最普遍的存在形式，对人类健康构成重大威胁。在这项研究中，我们研究了氟化物刺激在斑马鱼胚胎发生过程中引发的形态和生理变化，并揭示了其可能的阶段和/或剂量依赖性影响。氟化物具有很强的生物活性，可以被卵黄囊广泛吸收，并对多个器官的发育产生显著影响。这主要表现为限制营养物质的利用和脂质过氧化水平的升高，进一步导致卵黄囊、肝脏和肠道中超氧化物的积累。此外，心包水肿对脑和眼睛的发育施加压力，导致脊柱弯曲和体长缩短。此外，急性氟暴露具有不同浓度的致畸作用。低剂量的水氟化倾向于诱导胚胎卵黄囊的异常发育，而所有氟处理组都广泛观察到血管畸形。氟暴露对血液循环的影响普遍存在，即使在没有明显畸形的斑马鱼幼虫中也是如此。它们的游泳行为也受到水氟化的影响，导致活动减少和反应延迟。总之，本研究为监测与水氟化相关的环境质量和疾病预防提供了有价值的见解。
