Janssen Eline, van den Dries Koen, Ventre Maurizio, Cambi Alessandra
Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, the Netherlands.
Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125, Naples, Italy; Center for Advanced Biomaterials for Healthcare@CRIB, Fondazione Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, Naples, Italy; Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Italy.
Curr Opin Cell Biol. 2024 Feb;86:102311. doi: 10.1016/j.ceb.2023.102311. Epub 2024 Jan 4.
Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in the context of altered matrix mechanics in immune-related pathologies or in the response to implanted biomaterials. A detailed understanding of myeloid cell mechanosensing may eventually lead to more effective cell-based immunotherapies for cancer, the development of mechanically inspired therapies to target fibrosis, and the engineering of safer implants. This review covers these recent advances in the emerging field of mechanoimmunology of myeloid cells.
组织驻留髓系细胞能够感知并传导诸如硬度、拉伸和压缩等机械信号。在过去两年中，我们对髓系细胞中机械敏感信号通路的理解有了显著扩展。此外，越来越清楚的是哪些机械信号会诱导髓系细胞向促炎或抗炎表型转变。这在免疫相关疾病中基质力学改变的背景下或对植入生物材料的反应中尤为重要。对髓系细胞机械传感的详细理解最终可能会带来更有效的癌症细胞免疫疗法、开发针对纤维化的机械启发疗法以及设计更安全的植入物。本综述涵盖了髓系细胞机械免疫学这一新兴领域的这些最新进展。
