Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167010. doi: 10.1016/j.bbadis.2023.167010. Epub 2024 Jan 2.
Methyltransferase-like 3 (METTL3) is the most well-known element of N-methyladenosine modification on RNAs. METTL3 deposits a methyl group onto target RNAs to modify their expression, ultimately regulating various physiological and pathological events. Numerous studies have suggested the significant role of METTL3 in endocrine dysfunction and related disorders. However, reviews that summarize and interpret these studies are lacking. In this review, we systematically analyze such studies, including obesity, type 2 diabetes mellitus (T2DM), T2DM-induced diseases, pancreatic cancer, and thyroid carcinoma. This review indicates that METTL3 contributes remarkably to the endocrine dysfunction and progression of obesity, T2DM, T2DM-induced diseases, pancreatic cancer, and thyroid carcinoma. In conclusion, this review provides a comprehensive interpretation of the mechanism via which METTL3 functions on RNAs and regulates various endocrine dysfunction events and suggest potential associated correlations. Our review, thus, provides a valuable reference for further fundamental studies and clinical applications.
甲基转移酶样蛋白 3（METTL3）是 RNA 上 N6-甲基腺苷修饰最知名的元件。METTL3 将一个甲基基团沉积到靶 RNA 上，以修饰其表达，最终调节各种生理和病理事件。大量研究表明 METTL3 在内分泌功能障碍和相关疾病中具有重要作用。然而，缺乏对这些研究进行总结和解释的综述。在这篇综述中，我们系统地分析了这些研究，包括肥胖、2 型糖尿病（T2DM）、T2DM 相关疾病、胰腺癌和甲状腺癌。本综述表明，METTL3 对肥胖、T2DM、T2DM 相关疾病、胰腺癌和甲状腺癌的内分泌功能障碍和进展有显著贡献。总之，本综述提供了一个全面的解释，即 METTL3 通过 RNA 作用并调节各种内分泌功能障碍事件的机制，并提出了潜在的相关关联。因此，本综述为进一步的基础研究和临床应用提供了有价值的参考。
