Yamada S, Morohashi T
Nihon Yakurigaku Zasshi. 1986 Nov;88(5):395-401. doi: 10.1254/fpj.88.395.
Effect of sodium salicylate (SS) on renal handling and plasma concentration of calcium (Ca), phosphate (Pi) and magnesium (Mg) was studied in over-night fasted rats. Hypophosphatemic hypocalcemia was observed after the administration of 200 mg/kg of SS; on the other hand, hypermagnesemia was induced only with the dose of 400 mg/kg. A clearance study with the smaller dose of SS showed a decrease in urinary flow rate; however, the glomerular filtration rate remained unchanged. Reduction of urinary Ca excretion which was mainly due to a decreased filtered load was observed. On the other hand, we observed increased urinary excretion of Pi and decreased Mg excretion, which resulted from the changes in tubular reabsorption of Pi and Mg, respectively. It was concluded that the administration of SS caused a hypocalcemia by the action on a tissue other than the nephron, followed by a decreased filtered load, then a reduction of urinary Ca excretion. a decreased tubular reabsorption, which contributes to hypophosphatemia. However, the temporary increase in tubular reabsorption of Mg makes only a small contribution to the hypermagnesemia. It was suggested that an inhibition of cyclooxygenase was not related to these effects of salicylate on renal handling of these electrolytes.
在过夜禁食的大鼠中研究了水杨酸钠（SS）对肾脏处理以及钙（Ca）、磷（Pi）和镁（Mg）血浆浓度的影响。给予200mg/kg的SS后观察到低磷血症性低钙血症；另一方面，仅在剂量为400mg/kg时诱导出高镁血症。用较小剂量的SS进行的清除率研究显示尿流率降低；然而，肾小球滤过率保持不变。观察到尿钙排泄减少，这主要是由于滤过负荷降低所致。另一方面，我们观察到Pi的尿排泄增加而Mg排泄减少，这分别是由于Pi和Mg的肾小管重吸收变化所致。得出的结论是，SS的给药通过作用于肾单位以外的组织导致低钙血症，随后滤过负荷降低，然后尿钙排泄减少。肾小管重吸收减少，这导致了低磷血症。然而，Mg肾小管重吸收的暂时增加对高镁血症的影响很小。提示环氧化酶的抑制与水杨酸盐对这些电解质肾脏处理的这些作用无关。
