Department of Obstetrics, Jiangxi Provincial Maternal and Child Health Hospital, No. 318, Bayi Avenue, Nanchang, 330006, Jiangxi Province, China.
Department of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Sci Rep. 2024 Jan 4;14(1):513. doi: 10.1038/s41598-023-50914-7.
Ectodermal neural cortex 1 (ENC1) is a protein that plays a crucial role in the regulation of various cellular processes such as cell proliferation, differentiation, and apoptosis. Numerous studies have shown that ENC1 is overexpressed in various types of cancers, including breast, lung, pancreatic, and colorectal cancer, and its upregulation is correlated with a poorer prognosis. In addition to its role in cancer growth and spreading, ENC1 has also been linked to neuronal process development and neural crest cell differentiation. In this review, we provide an overview of the current knowledge on the relationship between ENC1 and cancer. We discuss the molecular mechanisms by which ENC1 contributes to tumorigenesis, including its involvement in multiple oncogenic signaling pathways. We also summarize the potential of targeting ENC1 for cancer therapy, as its inhibition has been shown to significantly reduce cancer cell invasion, growth, and metastasis. Finally, we highlight the remaining gaps in our understanding of ENC1's role in cancer and propose potential directions for future research.
外胚层神经皮质 1（ENC1）是一种在调节细胞增殖、分化和凋亡等多种细胞过程中发挥关键作用的蛋白质。大量研究表明，ENC1在多种类型的癌症中过度表达，包括乳腺癌、肺癌、胰腺癌和结直肠癌，其上调与预后不良相关。ENC1 除了在癌症生长和扩散中发挥作用外，还与神经元过程发育和神经嵴细胞分化有关。在这篇综述中，我们提供了关于 ENC1 与癌症关系的最新知识概述。我们讨论了 ENC1 促进肿瘤发生的分子机制，包括其参与多种致癌信号通路。我们还总结了针对 ENC1 进行癌症治疗的潜力，因为抑制 ENC1 已被证明可显著降低癌细胞的侵袭、生长和转移。最后，我们强调了我们对 ENC1 在癌症中的作用的理解仍存在差距，并提出了未来研究的潜在方向。
