Department of Health Policy, Prasanna School of Public Health (PSPH), Manipal Academy of Higher Education (MAHE), Manipal, Udupi, Karnataka, PIN 576104, India.
Department of International Health, Care and Public Health Research Institute - CAPHRI, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Syst Rev. 2024 Jan 5;13(1):14. doi: 10.1186/s13643-023-02415-x.
The HPV vaccine is characterized by its significant effectiveness in preventing the occurrence of cervical cancer. However, the South Asian countries face multiple challenges in implementing the human papillomavirus vaccine (HPV) at scale. Implementation of human papillomavirus vaccination for eliminating cervical cancer necessitates investigating the factors that impact the health system of these nations. Hence, this review will map the evidence on factors influencing the scaling up of human papillomavirus vaccination in South Asia.
The proposed scoping review will follow the steps given by Arksey and O'Malley and Levac et al. The search approach will follow McGowan et al. (14) evidence-based manual for Peer Analysis of Electronic Search Strategies (PRESS 2015) for systematic searches. Using a comprehensive search, the literature from 2006 onward will be identified from PubMed, CINAHL, EMBASE, Web of Science, and Scopus. The search strategy will include terms relating to the HPV vaccine and implementation. A predefined criterion for the inclusion and exclusion of studies will be adopted by three review authors independently to determine the eligible studies. The results will be narratively synthesized and examined in addition to being quantitatively presented to provide an outline. The review will be presented per the "Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review (PRISMA-ScR)" guidelines.
CONCLUSIONS/DISCUSSION: The evaluation is anticipated to map the barriers and enablers influencing the rollout of the human papillomavirus vaccine. Lessons learned from the South Asian countries, where the vaccine has been implemented, may contribute to aiding the implementation of the vaccine in countries with similar health systems in an effective manner.
The protocol was prospectively registered on the "open science framework". The registration DOI is https://doi.org/10.17605/OSF.IO/T5SW9 .
HPV 疫苗在预防宫颈癌发生方面具有显著的有效性。然而，南亚国家在大规模实施人乳头瘤病毒疫苗（HPV）方面面临多重挑战。实施 HPV 疫苗接种以消除宫颈癌需要调查影响这些国家卫生系统的因素。因此，本综述将绘制影响 HPV 疫苗在南亚扩大规模的因素的证据图谱。
拟议的范围综述将遵循 Arksey 和 O'Malley 以及 Levac 等人提出的步骤。搜索方法将遵循 McGowan 等人（14）针对电子搜索策略同行分析的循证手册（PRESS 2015）进行系统搜索。通过全面搜索，将从 PubMed、CINAHL、EMBASE、Web of Science 和 Scopus 中确定 2006 年以来的文献。搜索策略将包括与 HPV 疫苗和实施相关的术语。三位综述作者将采用预先确定的纳入和排除标准来独立确定合格的研究。结果将进行叙述性综合，并进行定量呈现，以提供概述。该综述将按照“系统评价和荟萃分析扩展的首选报告项目（PRISMA-ScR）”指南呈现。
结论/讨论：预计评估将绘制影响人乳头瘤病毒疫苗推出的障碍和促进因素。从已经实施疫苗的南亚国家吸取的经验教训可能有助于以有效的方式在具有类似卫生系统的国家中实施疫苗。
该方案已在“开放科学框架”上进行了前瞻性注册。注册 DOI 是 https://doi.org/10.17605/OSF.IO/T5SW9。
