Department of Sleep Medicine, Peking University Pepole's Hospital, 11 Xizhimennan Road, Beijing, 100044, China.
Sleep Center, Peking University International Hospital, Beijing, China.
Sleep Breath. 2024 Jun;28(3):1439-1448. doi: 10.1007/s11325-023-02981-3. Epub 2024 Jan 5.
Obstructive sleep apnea (OSA) is common in children with syndromic craniosynostosis (SC). However, objective data on the treatment of OSA in children with SC remain inadequate. This study aimed to explore the efficacy of continuous positive airway pressure (CPAP) in the management of OSA in children with SC.
A retrospective study was performed in children with SC and OSA diagnosed by polysomnography (PSG), which was defined as an apnea hypopnea index (AHI) ≥ 1. Patients were included if they were treated with CPAP and had baseline PSG and follow-up sleep studies. Clinical and demographic data were collected from all enrolled subjects.
A total of 45 children with SC and OSA were identified, with an average age of 6.8 ± 4.7 years. Among them, 36 cases had moderate to severe OSA (22 with severe OSA) and received CPAP therapy followed by post-treatment sleep studies. Notably, there was a significant reduction in the AHI observed after CPAP treatment (3.0 [IQR: 1.7, 4.6] versus 38.6 [IQR: 18.2, 53.3] events/h; P < 0.001).
CPAP is effective and acceptable in treating severe OSA in children with SC.
综合征型颅缝早闭（SC）患儿常伴有阻塞性睡眠呼吸暂停（OSA）。然而，关于 SC 患儿 OSA 治疗的客观数据仍然不足。本研究旨在探讨持续气道正压通气（CPAP）治疗 SC 患儿 OSA 的疗效。
对经多导睡眠图（PSG）诊断为 OSA 的 SC 患儿进行回顾性研究，定义为呼吸暂停低通气指数（AHI）≥1。纳入标准为接受 CPAP 治疗且有基线 PSG 和随访睡眠研究的患儿。所有入组患儿均收集临床和人口统计学资料。
共纳入 45 例 SC 合并 OSA 患儿，平均年龄为 6.8±4.7 岁。其中 36 例为中重度 OSA（22 例为重度 OSA），接受 CPAP 治疗后行睡眠研究。CPAP 治疗后 AHI 显著降低（3.0[IQR：1.7，4.6]比 38.6[IQR：18.2，53.3]事件/小时；P<0.001）。
CPAP 治疗 SC 患儿重度 OSA 有效且可接受。
