Heim-Duthoy K L, Halstenson C E, Abraham P A, Matzke G R
Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):680-4.
The disposition of piperacillin given as a 4 gm i.v. infusion was assessed during an interdialytic period and during hemodialysis in 12 chronic hemodialysis patients. Piperacillin concentrations in serum and dialysate were determined by HPLC. The half-life decreased from 2.84 +/- 2.04 h (mean +/- SD) during the interdialytic period to 1.30 +/- 0.43 h during the hemodialysis period (p = 0.008). Piperacillin total body clearance was 74.9 +/- 34.0 ml/min during the interdialytic period and the hemodialysis clearance was 92.4 +/- 30.0 ml/min. A significant change in the volume of distribution was observed from the interdialytic to dialytic period (0.21 +/- 0.06 vs 0.26 +/- 0.07 l/kg) (p = 0.026). A significant correlation between the hemodialysis clearance of piperacillin and hemodialysis clearance of creatinine and blood flow rate was also noted. No significant rebound in serum piperacillin concentrations was observed after cessation of hemodialysis. Approximately 46% of the amount of piperacillin in the body was removed by dialysis.
在12例慢性血液透析患者的透析间期和血液透析期间，评估了静脉输注4克哌拉西林后的处置情况。通过高效液相色谱法测定血清和透析液中的哌拉西林浓度。半衰期从透析间期的2.84±2.04小时（均值±标准差）降至血液透析期间的1.30±0.43小时（p = 0.008）。透析间期哌拉西林的全身清除率为74.9±34.0毫升/分钟，血液透析清除率为92.4±30.0毫升/分钟。从透析间期到透析期，分布容积发生了显著变化（0.21±0.06对0.26±0.07升/千克）（p = 0.026）。还注意到哌拉西林的血液透析清除率与肌酐的血液透析清除率和血流速度之间存在显著相关性。血液透析停止后，未观察到血清哌拉西林浓度有明显反弹。体内约46%的哌拉西林量通过透析清除。
