Kaplan S L, Berry P L, Mason E O, Kramer W G
Pediatr Pharmacol (New York). 1983;3(1):29-36.
Pharmacokinetics of moxalactam were determined in children with chronic renal failure during a 4-hour hemodialysis or an interdialytic period following a 50 mg/kg dose. Mean elimination half-life during dialysis was 3.9 hours compared to 12.9 hours during the interdialytic period. Mean clearance of moxalactam was 86 ml/minute during hemodialysis and 25 ml/minute between dialysis. Mean dialyzer clearance of moxalactam was 45 ml/minute. The mean fraction of moxalactam removed during a 4-hour hemodialysis was 18% in nine children. In anuric children, a 50 mg/kg dose of moxalactam should be given every 48 hours in an interdialytic period and a 25 mg/kg dose given after each dialysis.
对慢性肾衰竭儿童在接受50mg/kg剂量治疗后，于4小时血液透析期间或透析间期测定了拉氧头孢的药代动力学。透析期间的平均消除半衰期为3.9小时，而透析间期为12.9小时。血液透析期间拉氧头孢的平均清除率为86ml/分钟，透析间期为25ml/分钟。拉氧头孢的平均透析器清除率为45ml/分钟。9名儿童在4小时血液透析期间拉氧头孢的平均清除分数为18%。对于无尿儿童，在透析间期应每48小时给予50mg/kg剂量的拉氧头孢，每次透析后给予25mg/kg剂量。
