蛋白质组学：解析小细胞肺癌的新维度。
Proteomics: A new dimension to decode small cell lung cancer.
机构信息
Division of Oncology, Department of Medicine, Washington University in Saint Louis, St Louis, MO, USA.
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Cell. 2024 Jan 4;187(1):14-16. doi: 10.1016/j.cell.2023.11.042.
Abstract
Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and illustrate the potential of this knowledge to identify new SCLC vulnerabilities.
摘要
小细胞肺癌（SCLC）是一种难治性恶性肿瘤。要攻克它，就需要深入了解它的生物学特性。在本期《细胞》杂志中，Liu 及其同事描述了切除的 SCLC 肿瘤的蛋白质组和磷酸化蛋白质组图谱，并说明了这些知识识别新的 SCLC 弱点的潜力。
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