IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy.
IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-Oncologia, Milan, Italy.
Mol Cell. 2024 Jan 4;84(1):182-182.e1. doi: 10.1016/j.molcel.2023.11.031.
Completion of DNA replication relies on the ability of replication forks to traverse various types of DNA damage, actively transcribed regions, and structured DNA. The mechanisms enabling these processes are here referred to as DNA damage tolerance pathways. Here, we depict the stalled DNA replication fork structures with main DNA transactions and key factors contributing to the bypass of such blocks, replication restart, and completion. To view this SnapShot, open or download the PDF.
DNA 复制的完成依赖于复制叉跨越各种类型的 DNA 损伤、活跃转录区域和结构 DNA 的能力。使这些过程成为可能的机制在这里被称为 DNA 损伤容忍途径。在这里，我们描绘了带有主要 DNA 交易的停滞 DNA 复制叉结构，以及有助于绕过这些障碍、复制重新启动和完成的关键因素。要查看此快照，请打开或下载 PDF。
