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Online haemodiafiltration and all-cause mortality: how fragile are the results of the studies published so far?

作者信息

Battaglia Yuri, Mantovani Alessandro, Shroff Rukshana, Alfano Gaetano, Meijers Björn, Franssen Casper, Combe Christian, Basile Carlo

机构信息

University of Verona, Department of Medicine, Verona, Italy.

Pederzoli Hospital, Nephrology and Dialysis Unit, Peschiera del Garda, Italy.

出版信息

Nephrol Dial Transplant. 2024 May 31;39(6):1034-1036. doi: 10.1093/ndt/gfae003.

DOI:10.1093/ndt/gfae003
PMID:38183294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11139505/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/11139505/664107d388df/gfae003fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/11139505/664107d388df/gfae003fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/11139505/664107d388df/gfae003fig1.jpg

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Nephrol Dial Transplant. 2025 Aug 1;40(8):1590-1614. doi: 10.1093/ndt/gfaf024.
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Beyond the Fragility Index.超越脆弱性指数。
Pharm Stat. 2025 Mar-Apr;24(2):e2452. doi: 10.1002/pst.2452. Epub 2024 Nov 21.
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Does online high-volume hemodiafiltration offer greater efficiency and sustainability compared with high-flux hemodialysis? A detailed simulation analysis anchored in real-world data.

本文引用的文献

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The Robustness Index: Going Beyond Statistical Significance by Quantifying Fragility.稳健性指数:通过量化脆弱性超越统计显著性
Cureus. 2023 Aug 30;15(8):e44397. doi: 10.7759/cureus.44397. eCollection 2023 Aug.
2
Haemodiafiltration for all: are we CONVINCEd?全民血液透析滤过:我们信服了吗?
Nephrol Dial Transplant. 2023 Nov 30;38(12):2663-2665. doi: 10.1093/ndt/gfad136.
3
Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure.血液滤过或血液透析对肾衰竭死亡率的影响。
与高通量血液透析相比,在线大容量血液透析滤过是否具有更高的效率和可持续性?基于真实世界数据的详细模拟分析。
Clin Kidney J. 2024 May 10;17(6):sfae147. doi: 10.1093/ckj/sfae147. eCollection 2024 Jun.
4
Latest Trends in Hemodiafiltration.血液透析滤过的最新趋势
J Clin Med. 2024 Feb 16;13(4):1110. doi: 10.3390/jcm13041110.
N Engl J Med. 2023 Aug 24;389(8):700-709. doi: 10.1056/NEJMoa2304820. Epub 2023 Jun 16.
4
Statistical robustness of randomized controlled trials in high-impact journals has improved but was low across medical specialties.高影响力期刊中随机对照试验的统计稳健性有所提高,但在各医学专科中仍处于较低水平。
J Clin Epidemiol. 2022 Oct;150:165-170. doi: 10.1016/j.jclinepi.2022.07.001. Epub 2022 Jul 9.
5
Fragility indices for only sufficiently likely modifications.仅针对极有可能发生的修饰的脆性指数。
Proc Natl Acad Sci U S A. 2021 Dec 7;118(49). doi: 10.1073/pnas.2105254118.
6
Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors.评估免疫检查点抑制剂的 3 期临床试验的生存推断脆弱指数。
JAMA Netw Open. 2020 Oct 1;3(10):e2017675. doi: 10.1001/jamanetworkopen.2020.17675.
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Dismantling the Fragility Index: A demonstration of statistical reasoning.拆解脆弱指数:统计推理的演示。
Stat Med. 2020 Nov 20;39(26):3720-3731. doi: 10.1002/sim.8689. Epub 2020 Aug 11.
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The Use and Limitations of the Fragility Index in the Interpretation of Clinical Trial Findings.脆性指数在解读临床试验结果中的应用及局限性。
J Clin Psychiatry. 2020 Mar 24;81(2):20f13334. doi: 10.4088/JCP.20f13334.
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Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions.《可信系统评价的更新指南:干预措施系统评价的新版Cochrane手册》
Cochrane Database Syst Rev. 2019 Oct 3;10(10):ED000142. doi: 10.1002/14651858.ED000142.
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J Clin Epidemiol. 2019 Jul;111:32-40. doi: 10.1016/j.jclinepi.2019.03.012. Epub 2019 Mar 30.