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New evidence suggests SARS-CoV-2 neuroinvasion along the nervus terminalis rather than the olfactory pathway.

作者信息

von Bartheld Christopher S, Butowt Rafal

机构信息

Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557-0352, USA.

Medical Science Center, Faculty of Medicine, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland.

出版信息

Acta Neuropathol. 2024 Jan 6;147(1):10. doi: 10.1007/s00401-023-02664-z.

DOI:10.1007/s00401-023-02664-z
PMID:38183496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750156/
Abstract
摘要

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EBioMedicine. 2023 Oct;96:104784. doi: 10.1016/j.ebiom.2023.104784. Epub 2023 Sep 13.
2
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants.神经侵袭和嗅觉丧失是感染 SARS-CoV-2 及其变体时独立的现象。
Nat Commun. 2023 Jul 26;14(1):4485. doi: 10.1038/s41467-023-40228-7.
3
Mechanisms of SARS-CoV-2-associated anosmia.SARS-CoV-2 相关嗅觉丧失的机制。
新型冠状病毒肺炎嗅觉减退和味觉减退患者终神经、嗅束及嗅球的7特斯拉磁共振成像
Front Radiol. 2024 Oct 1;4:1322851. doi: 10.3389/fradi.2024.1322851. eCollection 2024.
4
Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects.与 COVID-19 相关的嗅觉丧失的受体：病理生理学和机制方面的最新进展。
Int J Mol Sci. 2024 Aug 5;25(15):8527. doi: 10.3390/ijms25158527.
5
The Neurological Implications of COVID-19: A Comprehensive Narrative Review.新型冠状病毒肺炎的神经学影响：一项全面的叙述性综述
Cureus. 2024 May 15;16(5):e60376. doi: 10.7759/cureus.60376. eCollection 2024 May.
6
Smelling TNT: Trends of the Terminal Nerve.嗅探 TNT：终端神经的趋势。
Int J Mol Sci. 2024 Mar 31;25(7):3920. doi: 10.3390/ijms25073920.
Physiol Rev. 2023 Oct 1;103(4):2759-2766. doi: 10.1152/physrev.00012.2023. Epub 2023 Jun 21.
4
Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms.新冠病毒感染导致的嗅觉功能障碍：潜在机制的新认识。
Trends Neurosci. 2023 Jan;46(1):75-90. doi: 10.1016/j.tins.2022.11.003. Epub 2022 Nov 16.
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Science. 2022 Jan 21;375(6578):267-269. doi: 10.1126/science.abm2052. Epub 2022 Jan 20.
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Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.血管紧张素转换酶2病毒进入蛋白在终神经中的表达揭示了新冠病毒感染大脑的另一条途径的可能性。
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10
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models.嗅觉神经不太可能是新冠病毒感染大脑的途径：对来自人类和动物模型数据的批判性综述
Acta Neuropathol. 2021 Jun;141(6):809-822. doi: 10.1007/s00401-021-02314-2. Epub 2021 Apr 26.